UniProt Accession

 ARPC5_HUMAN; O15511; A6NEC4; Q6PG42 

Genbank Protein ID

 AF006088; AF017807; AL137800; AL137800; CH471067; BC057237 

Genbank Nucleotide ID

 AAB64193.1; AAB70561.1; CAC19687.1; CAI19482.1; EAW91163.1; AAH57237.1 

Protein Name

 Actin-related protein 2/3 complex subunit 5 

Protein Synonyms/Alias

 Arp2/3 complex 16 kDa subunit; p16-ARC 

Gene Name

 ARPC5 

Gene Synonyms/Alias

 ARC16 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
3	*****MSKNTVSSAR	ubiquitination	[1, 2]
60	AALQAALKNPPINTK	ubiquitination	[1, 2, 3]
67	KNPPINTKSQAVKDR	ubiquitination	[1, 2, 3]
72	NTKSQAVKDRAGSIV	ubiquitination	[1]
87	LKVLISFKANDIEKA	ubiquitination	[1, 2]
93	FKANDIEKAVQSLDK	ubiquitination	[2, 3]
100	KAVQSLDKNGVDLLM	ubiquitination	[1, 2]
108	NGVDLLMKYIYKGFE	ubiquitination	[2, 3]
112	LLMKYIYKGFESPSD	ubiquitination	[1, 2, 4]
131	MLLQWHEKALAAGGV	ubiquitination	[2, 4, 5]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. 

Sequence Annotation

  

Keyword

 Actin-binding; Alternative splicing; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 151 AA 

Protein Sequence

Gene Ontology

 GO:0005885; C:Arp2/3 protein complex; TAS:ProtInc.
 GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005200; F:structural constituent of cytoskeleton; TAS:ProtInc.
 GO:0030036; P:actin cytoskeleton organization; TAS:ProtInc.
 GO:0006928; P:cellular component movement; TAS:ProtInc.
 GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; TAS:Reactome.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0030833; P:regulation of actin filament polymerization; IEA:InterPro. 

Interpro

 IPR006789; ARP2/3_p16_Arc. 

Pfam

 PF04699; P16-Arc 

SMART

  

PROSITE

  

PRINTS