| Tag | Content |
|---|
| CPLM ID | CPLM-023164 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Kinase D-interacting substrate of 220 kDa |
Protein Synonyms/Alias | Ankyrin repeat-rich membrane-spanning protein |
Gene Name | KIDINS220 |
Gene Synonyms/Alias | ARMS; KIAA1250 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 249 | IVRALLQKYADIDIR | ubiquitination | [1] | | 549 | ELPEQTTKALPVRFL | ubiquitination | [1] | | 695 | ASKLHKLKSEGFMKV | ubiquitination | [1] | | 849 | NSLGEMTKLGSKTAL | ubiquitination | [1] | | 853 | EMTKLGSKTALNRRD | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. May play a role in neurotrophin- and ephrin- mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. |
Sequence Annotation | REPEAT 4 33 ANK 1.
REPEAT 37 66 ANK 2.
REPEAT 70 99 ANK 3.
REPEAT 103 132 ANK 4.
REPEAT 136 165 ANK 5.
REPEAT 169 198 ANK 6.
REPEAT 202 231 ANK 7.
REPEAT 235 264 ANK 8.
REPEAT 268 297 ANK 9.
REPEAT 301 330 ANK 10.
REPEAT 334 363 ANK 11.
REPEAT 367 396 ANK 12.
DOMAIN 440 953 KAP NTPase.
REGION 1089 1092 Mediates interaction with CRKL (By
REGION 1767 1771 Mediates interaction with SNTA1 (By
MOD_RES 918 918 Phosphoserine.
MOD_RES 1365 1365 Phosphoserine.
MOD_RES 1521 1521 Phosphoserine.
MOD_RES 1555 1555 Phosphoserine.
MOD_RES 1633 1633 Phosphoserine. |
Keyword | Alternative splicing; ANK repeat; Complete proteome; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1771 AA |
Protein Sequence | MIAAEQGNLE IVKELIKNGA NCNLEDLDNW TALISASKEG HVHIVEELLK CGVNLEHRDM 60
GGWTALMWAC YKGRTDVVEL LLSHGANPSV TGLYSVYPII WAAGRGHADI VHLLLQNGAK 120
VNCSDKYGTT PLVWAARKGH LECVKHLLAM GADVDQEGAN SMTALIVAVK GGYTQSVKEI 180
LKRNPNVNLT DKDGNTALMI ASKEGHTEIV QDLLDAGTYV NIPDRSGDTV LIGAVRGGHV 240
EIVRALLQKY ADIDIRGQDN KTALYWAVEK GNATMVRDIL QCNPDTEICT KDGETPLIKA 300
TKMRNIEVVE LLLDKGAKVS AVDKKGDTPL HIAIRGRSRK LAELLLRNPK DGRLLYRPNK 360
AGETPYNIDC SHQKSILTQI FGARHLSPTE TDGDMLGYDL YSSALADILS EPTMQPPICV 420
GLYAQWGSGK SFLLKKLEDE MKTFAGQQIE PLFQFSWLIV FLTLLLCGGL GLLFAFTVHP 480
NLGIAVSLSF LALLYIFFIV IYFGGRREGE SWNWAWVLST RLARHIGYLE LLLKLMFVNP 540
PELPEQTTKA LPVRFLFTDY NRLSSVGGET SLAEMIATLS DACEREFGFL ATRLFRVFKT 600
EDTQGKKKWK KTCCLPSFVI FLFIIGCIIS GITLLAIFRV DPKHLTVNAV LISIASVVGL 660
AFVLNCRTWW QVLDSLLNSQ RKRLHNAASK LHKLKSEGFM KVLKCEVELM ARMAKTIDSF 720
TQNQTRLVVI IDGLDACEQD KVLQMLDTVR VLFSKGPFIA IFASDPHIII KAINQNLNSV 780
LRDSNINGHD YMRNIVHLPV FLNSRGLSNA RKFLVTSATN GDVPCSDTTG IQEDADRRVS 840
QNSLGEMTKL GSKTALNRRD TYRRRQMQRT ITRQMSFDLT KLLVTEDWFS DISPQTMRRL 900
LNIVSVTGRL LRANQISFNW DRLASWINLT EQWPYRTSWL ILYLEETEGI PDQMTLKTIY 960
ERISKNIPTT KDVEPLLEID GDIRNFEVFL SSRTPVLVAR DVKVFLPCTV NLDPKLREII 1020
ADVRAAREQI SIGGLAYPPL PLHEGPPRAP SGYSQPPSVC SSTSFNGPFA GGVVSPQPHS 1080
SYYSGMTGPQ HPFYNRGSGP APGPVVLLNS LNVDAVCEKL KQIEGLDQSM LPQYCTTIKK 1140
ANINGRVLAQ CNIDELKKEM NMNFGDWHLF RSTVLEMRNA ESHVVPEDPR FLSESSSGPA 1200
PHGEPARRAS HNELPHTELS SQTPYTLNFS FEELNTLGLD EGAPRHSNLS WQSQTRRTPS 1260
LSSLNSQDSS IEISKLTDKV QAEYRDAYRE YIAQMSQLEG GPGSTTISGR SSPHSTYYMG 1320
QSSSGGSIHS NLEQEKGKDS EPKPDDGRKS FLMKRGDVID YSSSGVSTND ASPLDPITEE 1380
DEKSDQSGSK LLPGKKSSER SSLFQTDLKL KGSGLRYQKL PSDEDESGTE ESDNTPLLKD 1440
DKDRKAEGKV ERVPKSPEHS AEPIRTFIKA KEYLSDALLD KKDSSDSGVR SSESSPNHSL 1500
HNEVADDSQL EKANLIELED DSHSGKRGIP HSLSGLQDPI IARMSICSED KKSPSECSLI 1560
ASSPEENWPA CQKAYNLNRT PSTVTLNNNS APANRANQNF DEMEGIRETS QVILRPSSSP 1620
NPTTIQNENL KSMTHKRSQR SSYTRLSKDP PELHAAASSE STGFGEERES IL 1672 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0000186; P:activation of MAPKK activity; TAS:Reactome. GO:0048813; P:dendrite morphogenesis; IEA:Compara. GO:0001701; P:in utero embryonic development; IEA:Compara. GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |