UniProt Accession

 SNX2_MOUSE; Q9CWK8; Q3UKW3; Q9CQV0 

Genbank Protein ID

 AK002692; AK005470; AK010572; AK075929; AK145840 

Genbank Nucleotide ID

 BAB22287.1; BAB24060.1; BAB27035.1; BAC36060.1; BAE26688.1 

Protein Name

 Sorting nexin-2 

Protein Synonyms/Alias

  

Gene Name

 Snx2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
116	IAPRIESKSISAPVI	acetylation	[1]
116	IAPRIESKSISAPVI	ubiquitination	[2]
167	MAYRVTTKTSLSMFS	ubiquitination	[2]
193	DFLGLHSKLASKYLH	ubiquitination	[2]
218	KSIVGMTKVKVGKED	ubiquitination	[2]
220	IVGMTKVKVGKEDSS	ubiquitination	[2]
223	MTKVKVGKEDSSSTE	ubiquitination	[2]
287	GILRMVNKAADAVNK	ubiquitination	[2]
346	ANTAAFAKSAAMLGN	ubiquitination	[2]
487	KERVKDFKAVIIKYL	acetylation	[3, 4]
487	KERVKDFKAVIIKYL	ubiquitination	[2]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 May be involved in several stages of intracellular trafficking. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). 

Sequence Annotation

 DOMAIN 140 269 PX.
 BINDING 183 183 Phosphatidylinositol 3-phosphate (By
 BINDING 185 185 Phosphatidylinositol 3-phosphate; via
 BINDING 211 211 Phosphatidylinositol 3-phosphate (By
 BINDING 235 235 Phosphatidylinositol 3-phosphate (By
 MOD_RES 119 119 Phosphoserine.
 MOD_RES 185 185 Phosphoserine.
 MOD_RES 277 277 Phosphoserine (By similarity).
 MOD_RES 469 469 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Endosome; Lipid-binding; Membrane; Phosphoprotein; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 519 AA 

Protein Sequence

Gene Ontology

 GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
 GO:0010008; C:endosome membrane; ISS:UniProtKB.
 GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
 GO:0008565; F:protein transporter activity; IEA:InterPro.
 GO:0007154; P:cell communication; IEA:InterPro.
 GO:0006886; P:intracellular protein transport; IEA:InterPro. 

Interpro

 IPR001683; Phox.
 IPR005329; Sorting_nexin_N.
 IPR015404; Vps5_C. 

Pfam

 PF00787; PX
 PF03700; Sorting_nexin
 PF09325; Vps5 

SMART

 SM00312; PX 

PROSITE

 PS50195; PX 

PRINTS