CPLM-022996

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-022996

UniProt Accession

MUTYH_HUMAN; Q9UIF7; D3DPZ4; Q15830; Q9UBP2; Q9UBS7; Q9UIF4; Q9UIF5; Q9UIF6

Genbank Protein ID

U63329; AB032920; AB032921; AB032922; AB032923; AB032924; AB032925; AB032926; AB032927; AB032928; AB032929; HQ205466; HQ205468; HQ205469; HQ205470; HQ205472; HQ205473; HQ205474; HQ205475; HQ205476; HQ205477; HQ205479; HQ205480; HQ205481; HQ205482; HQ205483; HQ205484; HQ205485; HQ205486; HQ205487; HQ205488; HQ205489; HQ205490; HQ205491; HQ205492; HQ205493; HQ205494; HQ205495; HQ205496; HQ205497; HQ205498; HQ205499; HQ205500; HQ205501; HQ205502; HQ205503; HQ205505; AF527839; AL359540; AL359540; AL359540; AL359540; AL359540; CH471059; CH471059; CH471059; BC003178

Genbank Nucleotide ID

AAC50618.1; BAA89336.1; BAA89337.1; BAA89338.1; BAA89339.1; BAA89340.1; BAA89341.1; BAA89342.1; BAA89343.1; BAA89344.1; BAA89345.1; ADP90937.1; ADP90947.1; ADP90952.1; ADP90957.1; ADP90967.1; ADP90972.1; ADP90977.1; ADP90982.1; ADP90987.1; ADP90992.1; ADP91002.1; ADP91007.1; ADP91012.1; ADP91017.1; ADP91022.1; ADP91027.1; ADP91032.1; ADP91037.1; ADP91042.1; ADP91047.1; ADP91052.1; ADP91057.1; ADP91062.1; ADP91067.1; ADP91072.1; ADP91077.1; ADP91082.1; ADP91087.1; ADP91092.1; ADP91097.1; ADP91102.1; ADP91107.1; ADP91112.1; ADP91117.1; ADP91122.1; ADP91132.1; AAM78555.1; CAI21713.1; CAI21714.1; CAI21718.1; CAI21719.1; CAI21720.1; EAX06993.1; EAX06996.1; EAX06997.1; AAH03178.1

Protein Name

A/G-specific adenine DNA glycosylase

Protein Synonyms/Alias

MutY homolog; hMYH

Gene Name

MUTYH

Gene Synonyms/Alias

MYH

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
41	EGRQKHAKNNSQAKP	ubiquitination	[1]
47	AKNNSQAKPSACDGL	ubiquitination	[1]
94	LSWYDQEKRDLPWRR	ubiquitination	[1]
178	RLQEGARKVVEELGG	ubiquitination	[1]
404	PSEQLQRKALLQELQ	ubiquitination	[1]
495	PGTCMGSKRSQVSSP	ubiquitination	[1]

Reference

[1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]

Functional Description

Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2- OH-A DNA glycosylase activities.

Sequence Annotation

DOMAIN 364 495 Nudix hydrolase.
MOTIF 404 426 Nudix box.
METAL 287 287 Iron-sulfur (4Fe-4S) (By similarity).
METAL 294 294 Iron-sulfur (4Fe-4S) (By similarity).
METAL 297 297 Iron-sulfur (4Fe-4S) (By similarity).
METAL 303 303 Iron-sulfur (4Fe-4S) (By similarity).

Keyword

3D-structure; 4Fe-4S; Alternative splicing; Complete proteome; Disease mutation; DNA damage; DNA repair; Glycosidase; Hydrolase; Iron; Iron-sulfur; Metal-binding; Nucleus; Polymorphism; Reference proteome; Tumor suppressor.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

546 AA

Protein Sequence

MTPLVSRLSR LWAIMRKPRA AVGSGHRKQA ASQEGRQKHA KNNSQAKPSA CDGLARQPEE 60
VVLQASVSSY HLFRDVAEVT AFRGSLLSWY DQEKRDLPWR RRAEDEMDLD RRAYAVWVSE 120
VMLQQTQVAT VINYYTGWMQ KWPTLQDLAS ASLEEVNQLW AGLGYYSRGR RLQEGARKVV 180
EELGGHMPRT AETLQQLLPG VGRYTAGAIA SIAFGQATGV VDGNVARVLC RVRAIGADPS 240
STLVSQQLWG LAQQLVDPAR PGDFNQAAME LGATVCTPQR PLCSQCPVES LCRARQRVEQ 300
EQLLASGSLS GSPDVEECAP NTGQCHLCLP PSEPWDQTLG VVNFPRKASR KPPREESSAT 360
CVLEQPGALG AQILLVQRPN SGLLAGLWEF PSVTWEPSEQ LQRKALLQEL QRWAGPLPAT 420
HLRHLGEVVH TFSHIKLTYQ VYGLALEGQT PVTTVPPGAR WLTQEEFHTA AVSTAMKKVF 480
RVYQGQQPGT CMGSKRSQVS SPCSRKKPRM GQQVLDNFFR SHISTDAHSL NSAAQ 535

Gene Ontology

GO:0005739; C:mitochondrion; IEA:Compara.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
GO:0004519; F:endonuclease activity; IEA:InterPro.
GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0032407; F:MutSalpha complex binding; IDA:HGNC.
GO:0045007; P:depurination; TAS:Reactome.
GO:0006298; P:mismatch repair; TAS:ProtInc.

Interpro

IPR011257; DNA_glycosylase.
IPR004036; Endonuclease-III_CS2.
IPR004035; Endouclease-III_FeS-bd_BS.
IPR003651; Endouclease3_FeS-loop_motif.
IPR003265; HhH-GPD_domain.
IPR023170; HTH_base_excis_C.
IPR000086; NUDIX_hydrolase_dom.
IPR015797; NUDIX_hydrolase_dom-like.

Pfam

PF00730; HhH-GPD

SMART

SM00478; ENDO3c
SM00525; FES

PROSITE

PS00764; ENDONUCLEASE_III_1
PS01155; ENDONUCLEASE_III_2
PS51462; NUDIX
PS00893; NUDIX_BOX

PRINTS