CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040905
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Tubby-related protein 3 
Protein Synonyms/Alias
  
Gene Name
 TULP3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
245ARKRKKSKTANYLISubiquitination[1, 2, 3, 4]
277RSNLMGTKFTVYDRGubiquitination[1, 3, 5]
316ETNVLGFKGPRKMSVubiquitination[2, 3, 5]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 501 AA 
Protein Sequence
MEASRCRLSP SGDSVFHEEM MKMRQAKLDY QRLLLEKRQR KKRLEPFMVQ PNPEARLRRA 60
KPRASDEQTP LVNCHTPHSN VILHGIDGPA AVLKPDEVHA PSVSSSVVEE DAENTVDTAS 120
KPGLQERLQK HDISESVNFD EETDGISQSA CLERPNSASS QNSTDTGTSG SATAAQPADN 180
LLGDIDDLED FVYSPAPQGV TVRCRIIRDK RGMDRGLFPT YYMYLEKEEN QKIFLLAARK 240
RKKSKTANYL ISIDPVDLSR EGESYVGKLR SNLMGTKFTV YDRGICPMKG RGLVGAAHTR 300
QELAAISYET NVLGFKGPRK MSVIIPGMTL NHKQIPYQPQ NNHDSLLSRW QNRTMENLVE 360
LHNKAPVWNS DTQSYVLNFR GRVTQASVKN FQIVHKNDPD YIVMQFGRVA DDVFTLDYNY 420
PLCAVQAFGI GLSSFDKCIQ TLRMQELCEL HRQHHSAASL VHRTVCQRWV GHPWRLLPQT 480
SLLWTDLSPP PVVPAPHQIS M 501 
Gene Ontology
 GO:0035085; C:cilium axoneme; IEA:Compara.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0060434; P:bronchus morphogenesis; IEA:Compara.
 GO:0021953; P:central nervous system neuron differentiation; IEA:Compara.
 GO:0031076; P:embryonic camera-type eye development; IEA:Compara.
 GO:0042733; P:embryonic digit morphogenesis; IEA:Compara.
 GO:0048702; P:embryonic neurocranium morphogenesis; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0021914; P:negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning; IEA:Compara.
 GO:0001843; P:neural tube closure; IEA:Compara.
 GO:0060831; P:smoothened signaling pathway involved in dorsal/ventral neural tube patterning; IEA:Compara. 
Interpro
 IPR000007; Tubby_C.
 IPR025659; Tubby_C-like.
 IPR018066; Tubby_C_CS.
 IPR005398; Tubby_N. 
Pfam
 PF01167; Tub 
SMART
  
PROSITE
 PS01200; TUB_1 
PRINTS
 PR01573; SUPERTUBBY.
 PR01574; TUBBYPROTEIN.