UniProt Accession

 BTUR_ECOLI; P0A9H5; P13040 

Genbank Protein ID

 M21528; U00096; AP009048 

Genbank Nucleotide ID

 AAA23530.1; AAC74352.1; BAA14807.1 

Protein Name

 Cob(I)yrinic acid a,c-diamide adenosyltransferase 

Protein Synonyms/Alias

 Cob(I)alamin adenosyltransferase; Corrinoid adenosyltransferase 

Gene Name

 btuR 

Gene Synonyms/Alias

 cobA; b1270; JW1262 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
66	VGVVQFIKGTWPNGE	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids (By similarity). 

Sequence Annotation

 NP_BIND 36 42 ATP (By similarity).  

Keyword

 ATP-binding; Cobalamin biosynthesis; Complete proteome; Cytoplasm; Nucleotide-binding; Porphyrin biosynthesis; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 196 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008817; F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity; ISS:EcoCyc.
 GO:0019250; P:aerobic cobalamin biosynthetic process; IMP:EcoCyc.
 GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW. 

Interpro

 IPR003724; AdoCbl_synth_CblAdoTrfase_CobA.
 IPR025826; Co_AT_N_dom.
 IPR027417; P-loop_NTPase. 

Pfam

 PF12557; Co_AT_N
 PF02572; CobA_CobO_BtuR 

SMART

  

PROSITE

  

PRINTS