CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020557
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ADP-ribosylation factor-like protein 8B 
Protein Synonyms/Alias
 ADP-ribosylation factor-like protein 10C; Novel small G protein indispensable for equal chromosome segregation 1 
Gene Name
 Arl8b 
Gene Synonyms/Alias
 Arl10c; Gie1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
62FNMRKVTKGNVTIKIubiquitination[1]
141LPNALDEKQLIEKMNubiquitination[1]
146DEKQLIEKMNLSAIQubiquitination[1]
182QWLIQHSKSRRS***ubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (By similarity). 
Sequence Annotation
 NP_BIND 29 35 GTP (By similarity).
 NP_BIND 71 75 GTP (By similarity).
 NP_BIND 130 133 GTP (By similarity).  
Keyword
 Cell cycle; Cell division; Chromosome partition; Complete proteome; Cytoplasm; Cytoskeleton; Endosome; GTP-binding; Lysosome; Membrane; Mitosis; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 186 AA 
Protein Sequence
MLALISRLLD WFRSLFWKEE MELTLVGLQY SGKTTFVNVI ASGQFSEDMI PTVGFNMRKV 60
TKGNVTIKIW DIGGQPRFRS MWERYCRGVN AIVYMIDAAD REKIEASRNE LHNLLDKPQL 120
QGIPVLVLGN KRDLPNALDE KQLIEKMNLS AIQDREICCY SISCKEKDNI DITLQWLIQH 180
SKSRRS 186 
Gene Ontology
 GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
 GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
 GO:0030496; C:midbody; IEA:Compara.
 GO:0051233; C:spindle midzone; IEA:Compara.
 GO:0019003; F:GDP binding; IEA:Compara.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR024156; Small_GTPase_ARF.
 IPR006689; Small_GTPase_ARF/SAR. 
Pfam
 PF00025; Arf 
SMART
 SM00177; ARF 
PROSITE
 PS51417; ARF 
PRINTS
 PR00328; SAR1GTPBP.