| Tag | Content |
|---|
| CPLM ID | CPLM-010992 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Nucleobindin-1 |
Protein Synonyms/Alias | CALNUC |
Gene Name | NUCB1 |
Gene Synonyms/Alias | NUC |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 302 | RMREHVMKNVDTNQD | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Major calcium-binding protein of the Golgi. May have a role in calcium homeostasis (By similarity). |
Sequence Annotation | DOMAIN 240 275 EF-hand 1.
DOMAIN 292 327 EF-hand 2.
DNA_BIND 172 218 Potential.
REGION 42 51 O-glycosylated at one site.
REGION 228 321 Binds to GNAI2 and GNAI3 (By similarity).
MOD_RES 86 86 Phosphoserine (By similarity).
MOD_RES 369 369 Phosphoserine (By similarity). |
Keyword | 3D-structure; Calcium; Coiled coil; Complete proteome; Cytoplasm; DNA-binding; Glycoprotein; Golgi apparatus; Membrane; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 461 AA |
Protein Sequence | MPPSGPRGTL LLLPLLLLLL LRAVLAVPLE RGAPNKEETP ATESPDTGLY YHRYLQEVID 60
VLETDGHFRE KLQAANAEDI KSGKLSRELD FVSHHVRTKL DELKRQEVSR LRMLLKAKMD 120
AEQDPNVQVD HLNLLKQFEH LDPQNQHTFE ARDLELLIQT ATRDLAQYDA AHHEEFKRYE 180
MLKEHERRRY LESLGEEQRK EAERKLEEQQ RRHREHPKVN VPGSQAQLKE VWEELDGLDP 240
NRFNPKTFFI LHDINSDGVL DEQELEALFT KELEKVYDPK NEEDDMREME EERLRMREHV 300
MKNVDTNQDR LVTLEEFLAS TQRKEFGDTG EGWETVEMHP AYTEEELRRF EEELAAREAE 360
LNAKAQRLSQ ETEALGRSQG RLEAQKRELQ QAVLHMEQRK QQQQQQQGHK APAAHPEGQL 420
KFHPDTDDVP VPAPAGDQKE VDTSEKKLLE RLPEVEVPQH L 461 |
Gene Ontology | GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IDA:UniProtKB. GO:0005615; C:extracellular space; TAS:ProtInc. GO:0005794; C:Golgi apparatus; IDA:HPA. GO:0016020; C:membrane; IEA:UniProtKB-KW. GO:0015630; C:microtubule cytoskeleton; IDA:HPA. GO:0005509; F:calcium ion binding; IEA:InterPro. GO:0003677; F:DNA binding; TAS:ProtInc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |