CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035403
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein Prmt5 
Protein Synonyms/Alias
 Protein arginine N-methyltransferase 5 (Predicted), isoform CRA_a 
Gene Name
 Prmt5 
Gene Synonyms/Alias
 Prmt5_predicted; rCG_23370 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
95PWIHPDSKVEKIRRNubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Methyltransferase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 637 AA 
Protein Sequence
MAAMAVGGAG GSRVSSGRDL NCVPEIADTL GAVAKQGFDF LCMPVFHPRF KREFIQEPAK 60
NRPGPQTRSD LLLSGRDWNT LIVGKLSPWI HPDSKVEKIR RNSEAAMLQE LNFGAYLGLP 120
AFLLPLNQED NTNLARVLTN HIHTGHHSSM FWMRVPLVAP EDLRDDVIEN APTAHTEEYS 180
GEEKTWLWWH NFRTLCDYSK RIAVALEIGA DLPSSHVIDR WLGEPIKAAI LPTSIFLTNK 240
KGFPVLSKMQ QRLIFRLLKL EVQFIITGTN HHSEKEFCSY LQYLEYLSQN RPPPNAYELF 300
AKGYEDYLQS PLQPLMDNLE SQTYEVFEKD PIKYSQYQQA IYKCLLDRVP EEEKETNVQV 360
LMVLGAGRGP LVNASLRAAK QAERRIRLYA VEKNPNAVVT LENWQFEEWG SQVTVVSSDM 420
REWVAPEKAD IIVSELLGSF ADNELSPECL DGAQHFLKDD GVSIPGEYTS FLAPISSSKL 480
YNEVRACREK DRDPEAQFEM PYVVRLHNFH QLSAPQPCFT FSHPNRDPMI DNNRYCTLEF 540
PVEVNTVLHG FAGYFETVLY RDITLSIRPE THSPGMFSWF PIFFPIKQPI TVHEGQNICV 600
RFWRCSNSKK VWYEWAVTAP VCSSIHNPTG RSYTIGL 637 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0043234; C:protein complex; IDA:RGD.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0035243; F:protein-arginine omega-N symmetric methyltransferase activity; IEA:Compara.
 GO:0043021; F:ribonucleoprotein complex binding; IEA:Compara.
 GO:0042118; P:endothelial cell activation; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0000387; P:spliceosomal snRNP assembly; IEA:Compara. 
Interpro
 IPR025799; Arg_MeTrfase.
 IPR007857; Arg_MeTrfase_PRMT5. 
Pfam
 PF05185; PRMT5 
SMART
  
PROSITE
 PS51632; SAM_PRMT_3 
PRINTS