| Tag | Content |
|---|
| CPLM ID | CPLM-011974 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Rho GTPase-activating protein 5 |
Protein Synonyms/Alias | Rho-type GTPase-activating protein 5; p190-B |
Gene Name | ARHGAP5 |
Gene Synonyms/Alias | RHOGAP5 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1053 | VPKTNVKKLDPNLLK | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | GTPase-activating protein for Rho family members. May play a role in the reduction of the p21rasGTPase-activating potential of RASA1/p120GAP. |
Sequence Annotation | DOMAIN 267 325 FF 1.
DOMAIN 366 420 FF 2.
DOMAIN 427 481 FF 3.
DOMAIN 482 548 FF 4.
DOMAIN 1262 1449 Rho-GAP.
MOD_RES 550 550 Nitrated tyrosine.
MOD_RES 765 765 Phosphoserine.
MOD_RES 951 951 Phosphoserine.
MOD_RES 968 968 Phosphoserine.
MOD_RES 1115 1115 Phosphoserine.
MOD_RES 1173 1173 Phosphoserine.
MOD_RES 1176 1176 Phosphoserine.
MOD_RES 1195 1195 Phosphoserine.
MOD_RES 1202 1202 Phosphoserine.
MOD_RES 1218 1218 Phosphoserine. |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; GTPase activation; Membrane; Nitration; Phosphoprotein; Polymorphism; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1502 AA |
Protein Sequence | MMAKNKEPRP PSYTISIVGL SGTEKDKGNC GVGKSCLCNR FVRSKADEYY PEHTSVLSTI 60
DFGGRVVNND HFLYWGDIIQ NSEDGVECKI HVIEQTEFID DQTFLPHRST NLQPYIKRAA 120
ASKLQSAEKL MYICTDQLGL EQDFEQKQMP EGKLNVDGFL LCIDVSQGCN RKFDDQLKFV 180
NNLFVQLSKS KKPVIIAATK CDECVDHYLR EVQAFASNKK NLLVVETSAR FNVNIETCFT 240
ALVQMLDKTR SKPKIIPYLD AYKTQRQLVV TATDKFEKLV QTVRDYHATW KTVSNKLKNH 300
PDYEEYINLE GTRKARNTFS KHIEQLKQEH IRKRREEYIN TLPRAFNTLL PNLEEIEHLN 360
WSEALKLMEK RADFQLCFVV LEKTPWDETD HIDKINDRRI PFDLLSTLEA EKVYQNHVQH 420
LISEKRRVEM KEKFKKTLEK IQFISPGQPW EEVMCFVMED EAYKYITEAD SKEVYGRHQR 480
EIVEKAKEEF QEMLFEHSEL FYDLDLNATP SSDKMSEIHT VLSEEPRYKA LQKLAPDRES 540
LLLKHIGFVY HPTKETCLSG QNCTDIKVEQ LLASSLLQLD HGRLRLYHDS TNIDKVNLFI 600
LGKDGLAQEL ANEIRTQSTD DEYALDGKIY ELDLRPVDAK SPYFLSQLWT AAFKPHGCFC 660
VFNSIESLSF IGEFIGKIRT EASQIRKDKY MANLPFTLIL ANQRDSISKN LPILRHQGQQ 720
LANKLQCPFV DVPAGTYPRK FNETQIKQAL RGVLESVKHN LDVVSPIPAN KDLSEADLRI 780
VMCAMCGDPF SVDLILSPFL DSHSCSAAQA GQNNSLMLDK IIGEKRRRIQ ITILSYHSSI 840
GVRKDELVHG YILVYSAKRK ASMGMLRAFL SEVQDTIPVQ LVAVTDSQAD FFENEAIKEL 900
MTEGEHIATE ITAKFTALYS LSQYHRQTEV FTLFFSDVLE KKNMIENSYL SDNTRESTHQ 960
SEDVFLPSPR DCFPYNNYPD SDDDTEAPPP YSPIGDDVQL LPTPSDRSRY RLDLEGNEYP 1020
IHSTPNCHDH ERNHKVPPPI KPKPVVPKTN VKKLDPNLLK TIEAGIGKNP RKQTSRVPLA 1080
HPEDMDPSDN YAEPIDTIFK QKGYSDEIYV VPDDSQNRIK IRNSFVNNTQ GDEENGFSDR 1140
TSKSHGERRP SKYKYKSKTL FSKAKSYYRR THSDASDDEA FTTSKTKRKG RHRGSEEDPL 1200
LSPVETWKGG IDNPAITSDQ ELDDKKMKKK THKVKEDKKQ KKKTKNFNPP TRRNWESNYF 1260
GMPLQDLVTA EKPIPLFVEK CVEFIEDTGL CTEGLYRVSG NKTDQDNIQK QFDQDHNINL 1320
VSMEVTVNAV AGALKAFFAD LPDPLIPYSL HPELLEAAKI PDKTERLHAL KEIVKKFHPV 1380
NYDVFRYVIT HLNRVSQQHK INLMTADNLS ICFWPTLMRP DFENREFLST TKIHQSVVET 1440
FIQQCQFFFY NGEIVETTNI VAPPPPSNPG QLVEPMVPLQ LPPPLQPQLI QPQLQTDPLG 1500
II 1502 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0016020; C:membrane; IEA:UniProtKB-SubCell. GO:0005525; F:GTP binding; IEA:InterPro. GO:0003924; F:GTPase activity; TAS:ProtInc. GO:0005100; F:Rho GTPase activator activity; TAS:ProtInc. GO:0007155; P:cell adhesion; TAS:ProtInc. GO:0030335; P:positive regulation of cell migration; IEA:Compara. GO:0002053; P:positive regulation of mesenchymal cell proliferation; IEA:Compara. GO:0008361; P:regulation of cell size; IEA:Compara. GO:0007266; P:Rho protein signal transduction; TAS:ProtInc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |