UniProt Accession

 BEX1_RAT; Q3MKQ2; Q6XUZ8 

Genbank Protein ID

 AY208292; AY833554 

Genbank Nucleotide ID

 AAP81280.1; AAX40672.1 

Protein Name

 Protein BEX1 

Protein Synonyms/Alias

 Brain-expressed X-linked protein 1 homolog; EG2RVC 

Gene Name

 Bex1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
4	****MESKDQGAKNL	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states. 

Sequence Annotation

 MOD_RES 105 105 Phosphoserine; by PKB/AKT1.  

Keyword

 Complete proteome; Cytoplasm; Developmental protein; Differentiation; Neurogenesis; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 128 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0045665; P:negative regulation of neuron differentiation; IDA:MGI.
 GO:0048011; P:neurotrophin TRK receptor signaling pathway; IGI:MGI.
 GO:0002052; P:positive regulation of neuroblast proliferation; IDA:MGI. 

Interpro

 IPR007623; BEX.
 IPR021156; TF_A-like/BEX-like. 

Pfam

 PF04538; BEX 

SMART

  

PROSITE

  

PRINTS