CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029986
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Scn2a1 
Protein Synonyms/Alias
  
Gene Name
 Scn2a1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
89DPYYINKKTFIVLNKubiquitination[1]
454QQMLEQLKKQQEEAQubiquitination[1]
455QMLEQLKKQQEEAQAubiquitination[1]
1019QKGIDFVKRKIREFIubiquitination[1]
1041QKALDEIKPLEDLNNubiquitination[1]
1049PLEDLNNKKDSCISNubiquitination[1]
1070GKDLNYLKDGNGTTSubiquitination[1]
1503KKYYNAMKKLGSKKPubiquitination[1]
1891FMASNPSKVSYEPITubiquitination[1]
1902EPITTTLKRKQEEVSubiquitination[1]
1904ITTTLKRKQEEVSAIubiquitination[1]
1937SSIYKKDKGKEDEGTubiquitination[1]
1939IYKKDKGKEDEGTPIubiquitination[1]
1947EDEGTPIKEDIITDKubiquitination[1]
1954KEDIITDKLNENSTPubiquitination[1]
1963NENSTPEKTDVTPSTubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Ion channel; Ion transport; Membrane; Reference proteome; Sodium; Sodium channel; Sodium transport; Transmembrane; Transport; Voltage-gated channel. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2006 AA 
Protein Sequence
MAQSVLVPPG PDSFRFFTRE SLAAIEQRIA EEKAKRPKQE RKDEDDENGP KPNSDLEAGK 60
SLPFIYGDIP PEMVSEPLED LDPYYINKKT FIVLNKGKAI SRFSATSALY ILTPFNPIRK 120
LAIKILVHSL FNVLIMCTIL TNCVFMTMSN PPDWTKNVEY TFTGIYTFES LIKILARGFC 180
LEDFTFLRDP WNWLDFTVIT FAYVTEFVNL GNVSALRTFR VLRALKTISV IPGLKTIVGA 240
LIQSVKKLSD VMILTVFCLS VFALIGLQLF MGNLRNKCLQ WPPDNSTFEI NITSFFNNSL 300
DWNGTAFNRT MNMFNWDEYI EDKSHFYFLE GQNDALLCGN SSDAGQCPEG YICVKAGRNP 360
NYGYTSFDTF SWAFLSLFRL MTQDFWENLY QLTLRAAGKT YMIFFVLVIF LGSFYLINLI 420
LAVVAMAYEE QNQATLEEAE QKEAEFQQML EQLKKQQEEA QAAAAAASAE SRDFSGAGGI 480
GVFSESSSVA SKLSSKSEKE LKNRRKKKKQ KEQAGEEEKE DAVRKSASED SIRKKGFRFS 540
LEGSRLTYEK RFSSPHQSLL SIRGSLFSPR RNSRASLFSF KGRVKDIGSE NDFADDEHST 600
FEDNDSRRDS LFVPHRHGER RPSNVSQASR ASRGIPTLPM NGKMHSAVDC NGVVSLVGGP 660
SALTSPVGQL LPEGTTTETE IRKRRSSSYH VSMDLLEDPT SRQRAMSMAS ILTNTMEELE 720
ESRQKCPPCW YKFANMCLIW DCCKPWLKVK HVVNLVVMDP FVDLAITICI VLNTLFMAME 780
HYPMTEQFSS VLSVGNLVFT GIFTAEMFLK IIAMDPYYYF QEGWNIFDGF IVSLSLMELG 840
LANVEGLSVL RSFRLLRVFK LAKSWPTLNM LIKIIGNSVG ALGNLTLVLA IIVFIFAVVG 900
MQLFGKSYKE CVCKISNDCE LPRWHMHDFF HSFLIVFRVL CGEWIETMWD CMEVAGQTMC 960
LTVFMMVMVI GNLVVLNLFL ALLLSSFSSD NLAATDDDNE MNNLQIAVGR MQKGIDFVKR 1020
KIREFIQKAF VRKQKALDEI KPLEDLNNKK DSCISNHTTI EIGKDLNYLK DGNGTTSGIG 1080
SSVEKYVVDE SDYMSFINNP SLTVTVPIAV GESDFENLNT EEFSSESDME ESKEKLNATS 1140
SSEGSTVDIG APAEGEQPEA EPEESLEPEA CFTEDCVRKF KCCQISIEEG KGKLWWNLRK 1200
TCYKIVEHNW FETFIVFMIL LSSGALAFED IYIEQRKTIK TMLEYADKVF TYIFILEMLL 1260
KWVAYGFQMY FTNAWCWLDF LIVDVSLVSL TANALGYSEL GAIKSLRTLR ALRPLRALSR 1320
FEGMRVVVNA LLGAIPSIMN VLLVCLIFWL IFSIMGVNLF AGKFYHCINY TTGEMFDVSV 1380
VNNYSECQAL IESNQTARWK NVKVNFDNVG LGYLSLLQVA TFKGWMDIMY AAVDSRNVEL 1440
QPKYEDNLYM YLYFVIFIIF GSFFTLNLFI GVIIDNFNQQ KKKFGGQDIF MTEEQKKYYN 1500
AMKKLGSKKP QKPIPRPANK FQGMVFDFVT KQVFDISIMI LICLNMVTMM VETDDQSQEM 1560
TNILYWINLV FIVLFTGECV LKLISLRHYY FTIGWNIFDF VVVILSIVGM FLAELIEKYF 1620
VSPTLFRVIR LARIGRILRL IKGAKGIRTL LFALMMSLPA LFNIGLLLFL VMFIYAIFGM 1680
SNFAYVKREV GIDDMFNFET FGNSMICLFQ ITTSAGWDGL LAPILNSGPP DCDPEKDHPG 1740
SSVKGDCGNP SVGIFFFVSY IIISFLVVVN MYIAVILENF SVATEESAEP LSEDDFEMFY 1800
EVWEKFDPDA TQFIEFCKLS DFAAALDPPL LIAKPNKVQL IAMDLPMVSG DRIHCLDILF 1860
AFTKRVLGES GEMDALRIQM EERFMASNPS KVSYEPITTT LKRKQEEVSA IVIQRAYRRY 1920
LLKQKVKKVS SIYKKDKGKE DEGTPIKEDI ITDKLNENST PEKTDVTPST TSPPSYDSVT 1980
KPEKEKFEKD KSEKEDKGKD IRESKK 2006 
Gene Ontology
 GO:0014704; C:intercalated disc; IDA:MGI.
 GO:0033270; C:paranode region of axon; IDA:MGI.
 GO:0030315; C:T-tubule; IDA:MGI.
 GO:0001518; C:voltage-gated sodium channel complex; TAS:MGI.
 GO:0005248; F:voltage-gated sodium channel activity; IDA:MGI.
 GO:0008627; P:intrinsic apoptotic signaling pathway in response to osmotic stress; IMP:MGI.
 GO:0007399; P:nervous system development; IMP:MGI.
 GO:0051402; P:neuron apoptotic process; IMP:MGI. 
Interpro
 IPR024583; DUF3451.
 IPR005821; Ion_trans_dom.
 IPR000048; IQ_motif_EF-hand-BS.
 IPR027359; K_channel_four-helix_dom.
 IPR001696; Na_channel_asu.
 IPR010526; Na_trans_assoc. 
Pfam
 PF11933; DUF3451
 PF00520; Ion_trans
 PF06512; Na_trans_assoc 
SMART
 SM00015; IQ 
PROSITE
 PS50096; IQ 
PRINTS
 PR00170; NACHANNEL.