Tag | Content |
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CPLM ID | CPLM-011564 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Adenylyl cyclase-associated protein 1 |
Protein Synonyms/Alias | CAP 1 |
Gene Name | Cap1 |
Gene Synonyms/Alias | Cap; Mch1 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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62 | AEYLKMSKEIGGDVQ | acetylation | [1] | 70 | EIGGDVQKHAEMVHT | acetylation | [1] | 80 | EMVHTGLKLERALLV | acetylation | [1] | 169 | FYTNRVLKEYRDVDK | acetylation | [1] | 176 | KEYRDVDKKHVDWVR | acetylation | [1] | 177 | EYRDVDKKHVDWVRA | acetylation | [1] | 208 | TTGLAWSKTGPVAKE | acetylation | [1] | 297 | GPVRSGPKPFSAPKP | acetylation | [1] | 326 | ALLELEGKKWRVENQ | acetylation | [1] | 347 | VIDDTELKQVAYIYK | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity (By similarity). |
Sequence Annotation | DOMAIN 312 452 C-CAP/cofactor C-like. MOD_RES 2 2 N-acetylalanine (By similarity). MOD_RES 34 34 Phosphoserine (By similarity). MOD_RES 80 80 N6-acetyllysine (By similarity). MOD_RES 289 289 Phosphoserine (By similarity). MOD_RES 294 294 Phosphoserine (By similarity). MOD_RES 300 300 Phosphoserine (By similarity). MOD_RES 306 306 Phosphothreonine (By similarity). MOD_RES 307 307 Phosphoserine (By similarity). MOD_RES 309 309 Phosphoserine (By similarity). |
Keyword | Acetylation; Actin-binding; Cell membrane; Complete proteome; Direct protein sequencing; Membrane; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 474 AA |
Protein Sequence | MADMQNLVER LERAVGRLEA VSHTSDMHCG YGDSPSKGAV PYVQAFDSLL ANPVAEYLKM 60 SKEIGGDVQK HAEMVHTGLK LERALLVTAS QCQQPAGNKL SDLLAPISEQ IQEVITFREK 120 NRGSKFFNHL SAVSESIQAL GWVALAAKPG PFVKEMNDAA MFYTNRVLKE YRDVDKKHVD 180 WVRAYLSIWT ELQAYIKEFH TTGLAWSKTG PVAKELSGLP SGPSVGSGPP PPPPGPPPPP 240 VPTSSGSDDS ASRSALFAQI NQGESITHAL KHVSDDMKTH KNPALKAQSG PVRSGPKPFS 300 APKPQTSPSP KPATKKEPAL LELEGKKWRV ENQENVSNLV IDDTELKQVA YIYKCVNTTL 360 QIKGKINSIT VDNCKKLGLV FDDVVGIVEI INSRDVKVQV MGKVPTISIN KTDGCHAYLS 420 KNSLDCEIVS AKSSEMNVLI PTEGGDFNEF PVPEQFKTLW NGQKLVTTVT EIAG 474 |
Gene Ontology | GO:0030864; C:cortical actin cytoskeleton; IEA:Compara. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0030036; P:actin cytoskeleton organization; IEA:Compara. GO:0001667; P:ameboidal cell migration; IEA:Compara. GO:0000902; P:cell morphogenesis; IEA:Compara. GO:0006898; P:receptor-mediated endocytosis; IEA:Compara. |
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