UniProt Accession

 B2M1R6_MOUSE; B2M1R6 

Genbank Protein ID

 AC154437; EU604547 

Genbank Nucleotide ID

 ACC69193.1 

Protein Name

 Heterogeneous nuclear ribonucleoprotein K 

Protein Synonyms/Alias

  

Gene Name

 Hnrnpk 

Gene Synonyms/Alias

 Hnrpk 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
21	ETNGEFGKRPAEDME	acetylation	[1]
34	MEEEQAFKRSRNTDE	acetylation	[2, 3]
34	MEEEQAFKRSRNTDE	ubiquitination	[4]
52	LRILLQSKNAGAVIG	acetylation	[2]
52	LRILLQSKNAGAVIG	ubiquitination	[4]
60	NAGAVIGKGGKNIKA	ubiquitination	[4]
66	GKGGKNIKALRTDYN	ubiquitination	[4]
139	AGGIIGVKGAKIKEL	ubiquitination	[4]
155	ENTQTTIKLFQECCP	acetylation	[2]
155	ENTQTTIKLFQECCP	ubiquitination	[4]
174	RVVLIGGKPDRVVEC	acetylation	[3]
174	RVVLIGGKPDRVVEC	ubiquitination	[4]
195	LISESPIKGRAQPYD	acetylation	[3]
195	LISESPIKGRAQPYD	succinylation	[3]
195	LISESPIKGRAQPYD	ubiquitination	[4]
372	TTQVTIPKDLAGSII	ubiquitination	[4]
381	LAGSIIGKGGQRIKQ	acetylation	[2, 3]
381	LAGSIIGKGGQRIKQ	succinylation	[3]
381	LAGSIIGKGGQRIKQ	ubiquitination	[4]
398	HESGASIKIDEPLEG	acetylation	[1, 3]
398	HESGASIKIDEPLEG	succinylation	[3]
398	HESGASIKIDEPLEG	ubiquitination	[4]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome; Ribonucleoprotein; Viral nucleoprotein; Virion. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 440 AA 

Protein Sequence

Gene Ontology

 GO:0030529; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
 GO:0003723; F:RNA binding; IDA:MGI.
 GO:0042981; P:regulation of apoptotic process; IMP:MGI. 

Interpro

 IPR004087; KH_dom.
 IPR004088; KH_dom_type_1.
 IPR012987; ROK_N. 

Pfam

 PF00013; KH_1
 PF13014; KH_3
 PF08067; ROKNT 

SMART

 SM00322; KH 

PROSITE

 PS50084; KH_TYPE_1 

PRINTS