| Tag | Content |
|---|
| CPLM ID | CPLM-010488 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Cyclic AMP-dependent transcription factor ATF-1 |
Protein Synonyms/Alias | cAMP-dependent transcription factor ATF-1; Activating transcription factor 1; TCR-ATF1 |
Gene Name | Atf1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 258 | KTLIEELKTLKDLYS | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Binds the cAMP response element (CRE) (consensus: 5'- GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation (By similarity). |
Sequence Annotation | DOMAIN 31 90 KID.
DOMAIN 211 269 bZIP.
REGION 213 237 Basic motif (By similarity).
REGION 239 260 Leucine-zipper (By similarity).
MOD_RES 63 63 Phosphoserine; by CaMK1, CDK3, RPS6KA4
MOD_RES 196 196 Phosphoserine; by HIPK2 (By similarity). |
Keyword | Activator; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 269 AA |
Protein Sequence | MEDSHKSNTT ETASQPGSTV AGPHVSQIVH QVSSLSESEE SQDSSDSIGS SQKAHGILAR 60
RPSYRKILKD LSSEDTRGRK GEGENPSISA ITSMSVPAPI YQTSSGQYIA IAPNGALQLA 120
SPSTDGVQAL QTLTMTNSSS TQQGTILQYA QTSDGQQILV PSNQVVVQTA SGDMQTYQIR 180
TTPSATSLPQ TVVMTSPVTL ASQTTKTDDP QLRREIRLMK NREAARECRR KKKEYVKCLE 240
NRVAVLENQN KTLIEELKTL KDLYSHKSV 269 |
Gene Ontology | GO:0005667; C:transcription factor complex; IDA:MGI. GO:0003677; F:DNA binding; IDA:MGI. GO:0043565; F:sequence-specific DNA binding; IEA:InterPro. GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |