UniProt Accession

 APOA4_MOUSE; P06728; Q91XF8 

Genbank Protein ID

 M13966; M64248; M64249; AK161535; AK168687; CH466522; BC010769 

Genbank Nucleotide ID

 AAA37253.1; AAA37214.1; AAA37215.1; BAE36447.1; BAE40533.1; EDL25684.1; AAH10769.1 

Protein Name

 Apolipoprotein A-IV 

Protein Synonyms/Alias

 Apo-AIV; ApoA-IV; Apolipoprotein A4 

Gene Name

 Apoa4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
51	EAVEQFQKTDVTQQL	acetylation	[1]
136	QKLQEHLKPYAVDLQ	acetylation	[1]

Reference

 [1] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379] 

Functional Description

 May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons. 

Sequence Annotation

 REPEAT 33 54 1.
 REPEAT 60 81 2.
 REPEAT 82 103 3.
 REPEAT 115 136 4.
 REPEAT 137 158 5.
 REPEAT 159 180 6.
 REPEAT 181 202 7.
 REPEAT 203 224 8.
 REPEAT 225 246 9.
 REPEAT 247 268 10.
 REPEAT 269 286 11.
 REPEAT 287 308 12.
 REPEAT 309 330 13.
 REGION 33 330 13 X 22 AA approximate tandem repeats.  

Keyword

 Chylomicron; Complete proteome; HDL; Lipid transport; Polymorphism; Reference proteome; Repeat; Secreted; Signal; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 395 AA 

Protein Sequence

Gene Ontology

 GO:0009986; C:cell surface; IEA:Compara.
 GO:0042627; C:chylomicron; IEA:UniProtKB-KW.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005615; C:extracellular space; IDA:MGI.
 GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
 GO:0034361; C:very-low-density lipoprotein particle; IEA:Compara.
 GO:0016209; F:antioxidant activity; IEA:Compara.
 GO:0017127; F:cholesterol transporter activity; IEA:Compara.
 GO:0005507; F:copper ion binding; IEA:Compara.
 GO:0031210; F:phosphatidylcholine binding; IEA:Compara.
 GO:0060228; F:phosphatidylcholine-sterol O-acyltransferase activator activity; IEA:Compara.
 GO:0033344; P:cholesterol efflux; IEA:Compara.
 GO:0042632; P:cholesterol homeostasis; IEA:Compara.
 GO:0008203; P:cholesterol metabolic process; IEA:Compara.
 GO:0042744; P:hydrogen peroxide catabolic process; IEA:Compara.
 GO:0002227; P:innate immune response in mucosa; IMP:BHF-UCL.
 GO:0007159; P:leukocyte cell-cell adhesion; IEA:Compara.
 GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
 GO:0044240; P:multicellular organismal lipid catabolic process; IEA:Compara.
 GO:0034445; P:negative regulation of plasma lipoprotein particle oxidation; IEA:Compara.
 GO:0046470; P:phosphatidylcholine metabolic process; IEA:Compara.
 GO:0033700; P:phospholipid efflux; IEA:Compara.
 GO:0010873; P:positive regulation of cholesterol esterification; IEA:Compara.
 GO:0045723; P:positive regulation of fatty acid biosynthetic process; IEA:Compara.
 GO:0051006; P:positive regulation of lipoprotein lipase activity; IEA:Compara.
 GO:0010898; P:positive regulation of triglyceride catabolic process; IEA:Compara.
 GO:0065005; P:protein-lipid complex assembly; IEA:Compara.
 GO:0030300; P:regulation of intestinal cholesterol absorption; IMP:MGI.
 GO:0019430; P:removal of superoxide radicals; IEA:Compara.
 GO:0006982; P:response to lipid hydroperoxide; IEA:Compara.
 GO:0035634; P:response to stilbenoid; IEP:UniProtKB.
 GO:0043691; P:reverse cholesterol transport; IEA:Compara.
 GO:0034372; P:very-low-density lipoprotein particle remodeling; IEA:Compara. 

Interpro

 IPR013326; ApoA.
 IPR000074; ApoA1_A4_E. 

Pfam

 PF01442; Apolipoprotein 

SMART

  

PROSITE

  

PRINTS