UniProt Accession

 HNRPD_MOUSE; Q60668; Q60667; Q80ZJ0; Q91X94 

Genbank Protein ID

 U11273; U11274; BC011172; BC049098 

Genbank Nucleotide ID

 AAA64653.1; AAA64654.1; AAH11172.2; AAH49098.1 

Protein Name

 Heterogeneous nuclear ribonucleoprotein D0 

Protein Synonyms/Alias

 hnRNP D0; AU-rich element RNA-binding protein 1 

Gene Name

 Hnrnpd 

Gene Synonyms/Alias

 Auf1; Hnrpd 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
110	GLSWDTTKKDLKDYF	ubiquitination	[1]
114	DTTKKDLKDYFSKFG	ubiquitination	[1]
119	DLKDYFSKFGEVVDC	ubiquitination	[1]
153	KESESVDKVMDQKEH	ubiquitination	[1]
197	SPDTPEEKIREYFGG	ubiquitination	[1]
218	IELPMDNKTNKRRGF	ubiquitination	[1]
237	FKEEEPVKKIMEKKY	ubiquitination	[1]
251	YHNVGLSKCEIKVAM	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto- oncogenes and cytokine mRNAs. Also binds to double- and single- stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'- TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity). 

Sequence Annotation

 DOMAIN 97 179 RRM 1.
 DOMAIN 182 261 RRM 2.
 MOD_RES 71 71 Phosphoserine (By similarity).
 MOD_RES 80 80 Phosphoserine.
 MOD_RES 82 82 Phosphoserine (By similarity).
 MOD_RES 83 83 Phosphoserine.
 MOD_RES 119 119 N6-methyllysine (By similarity).
 MOD_RES 165 165 N6-acetyllysine (By similarity).
 MOD_RES 190 190 Phosphoserine (By similarity).
 MOD_RES 193 193 Phosphothreonine (By similarity).
 MOD_RES 251 251 N6-acetyllysine (By similarity).
 MOD_RES 345 345 Dimethylated arginine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; DNA-binding; Methylation; Nucleus; Phosphoprotein; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 355 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0030529; C:ribonucleoprotein complex; ISS:UniProtKB.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; ISS:UniProtKB.
 GO:0042162; F:telomeric DNA binding; ISS:UniProtKB.
 GO:0043488; P:regulation of mRNA stability; IMP:MGI.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR012956; CARG-binding_factor_N.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF08143; CBFNT
 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS