CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040751
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Pleckstrin homology domain-containing family M member 1 
Protein Synonyms/Alias
  
Gene Name
 PLEKHM1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
427AAPSQGHKSFRVVHRubiquitination[1]
513ELVFSGKKLALRASSubiquitination[1]
631FRIRNNEKMLSDSHGubiquitination[2]
790IHNWDLTKRPICRQAubiquitination[1]
837GRRREQLKLLGDYLGubiquitination[1]
852LCRSGALKELSKRLNubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 967 AA 
Protein Sequence
MDWTPRLPSR HIISELEHLT FVNTDVGRCR AWLRLALNDG LMECYLKLLL QEQARLHEYY 60
QPTALLRDAE EGEFLLSFLQ GLTSLSFELS YKSAILNEWT LTPLALSGLC PLSELDPLST 120
SGAELQRKES LDSISHSSGS EDIEVHHSGH KIRRNQKLTA SSLSLDTASS SQLSCSLNSD 180
SCLLQENGSK SPDHCEEPMS CDSDLGTANA EDSDRSLQEV LLEFSKAQVN SVPTNGLSQE 240
TEIPTPQASL SLHGLNTSTY LHCEAPAEPL PAQAASGTQD GVHVQEPRPQ APSPLDLQQP 300
VESTSGQQPS STVSETAREV GQGNGLQKAQ AHDGAGLKLV VSSPTSPKNK SWISEDDFYR 360
PSREQPLESA SDHPIASYRG TPGSRPGLHR HFSQEPRKNC SLGALDQACV PSPGRRQAQA 420
APSQGHKSFR VVHRRQMGLS NPFRGLMKLG TVERRGAMGI WKELFCELSP LEFRLYLSNE 480
EHTCVENCSL LRCESVGPAH SDGRFELVFS GKKLALRASS QDEAEDWLDR VREALQKVRP 540
QQEDEWVNVQ YPDQPEEPPE APQGCLSPSD LLSEPAALQG TQFDWSSAQV PEPDAIKESL 600
LYLYMDRTWM PYIFSLSLEA LKCFRIRNNE KMLSDSHGVE TIRDILPDTS LGGPSFFKII 660
TAKAVLKLQA GNAEEAALWR DLVRKVLASY LETAEEAVTL GGSLDENCQE VLKFATRENG 720
FLLQYLVAIP MEKGLDSQGC FCAGCSRQIG FSFVRPKLCA FSGLYYCDIC HQDDASVIPA 780
RIIHNWDLTK RPICRQALKF LTQIRAQPLI NLQMVNASLY EHVERMHLIG RRREQLKLLG 840
DYLGLCRSGA LKELSKRLNH RNYLLESPHR FSVADLQQIA DGVYEGFLKA LIEFASQHVY 900
HCDLCTQRGF ICQICQHHDI IFPFEFDTTV RCAECKTVFH QSCQAVVKKG CPRCARRRKY 960
QEQNIFA 967 
Gene Ontology
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro. 
Interpro
 IPR025258; DUF4206.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
 IPR004012; Run. 
Pfam
 PF13901; DUF4206
 PF02759; RUN 
SMART
 SM00109; C1
 SM00233; PH
 SM00593; RUN 
PROSITE
 PS50003; PH_DOMAIN
 PS50826; RUN
 PS50081; ZF_DAG_PE_2 
PRINTS