UniProt Accession

 DHB7_MOUSE; O88736; Q8K5C9; Q921L1 

Genbank Protein ID

 Y15733; AJ291459; AJ291460; AJ291461; AJ291463; AJ291465; AJ291466; AJ291464; AJ291462; AK028380; AK050211; BC011464; AF367475 

Genbank Nucleotide ID

 CAA75742.1; CAC88119.1; CAC88119.1; CAC88119.1; CAC88119.1; CAC88119.1; CAC88119.1; CAC88119.1; CAC88119.1; BAC25918.1; BAC34124.1; AAM21211.1 

Protein Name

 3-keto-steroid reductase 

Protein Synonyms/Alias

 17-beta-hydroxysteroid dehydrogenase 7; 17-beta-HSD 7; Estradiol 17-beta-dehydrogenase 7 

Gene Name

 Hsd17b7 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
188	LEDIQHSKGPEPYSS	ubiquitination	[1]
197	PEPYSSSKYATDLLN	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Responsible for the reduction of the keto group on the C-3 of sterols. 

Sequence Annotation

 NP_BIND 8 15 NAD (Potential).
 ACT_SITE 193 193 Proton acceptor (By similarity).
 BINDING 171 171 Substrate (By similarity).
 CARBOHYD 37 37 N-linked (GlcNAc...) (Potential).
 CARBOHYD 127 127 N-linked (GlcNAc...) (Potential).
 CARBOHYD 178 178 N-linked (GlcNAc...) (Potential).
 CARBOHYD 229 229 N-linked (GlcNAc...) (Potential).  

Keyword

 Cell membrane; Complete proteome; Glycoprotein; Lipid biosynthesis; Lipid metabolism; Membrane; NAD; NADP; Oxidoreductase; Reference proteome; Steroid biosynthesis; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 334 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0000253; F:3-keto sterol reductase activity; IDA:MGI.
 GO:0004303; F:estradiol 17-beta-dehydrogenase activity; IEA:EC.
 GO:0006695; P:cholesterol biosynthetic process; IDA:MGI.
 GO:0006703; P:estrogen biosynthetic process; IEA:UniProtKB-UniPathway. 

Interpro

 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF00106; adh_short 

SMART

  

PROSITE

 PS00061; ADH_SHORT 

PRINTS

 PR00081; GDHRDH.