CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005349
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Regulator of chromosome condensation 
Protein Synonyms/Alias
 Chromatin-binding protein Bj1 
Gene Name
 Bj1 
Gene Synonyms/Alias
 CG10480 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
281LAHETKGKEFALTPIacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds to the chromatin. 
Sequence Annotation
 REPEAT 41 91 RCC1 1.
 REPEAT 92 143 RCC1 2.
 REPEAT 145 195 RCC1 3.
 REPEAT 197 257 RCC1 4.
 REPEAT 260 310 RCC1 5.
 REPEAT 311 362 RCC1 6.
 REPEAT 363 416 RCC1 7.
 REPEAT 417 454 Bj1 1.
 REPEAT 455 489 Bj1 2.
 REPEAT 490 519 Bj1 3.
 MOD_RES 286 286 Phosphothreonine.
 MOD_RES 512 512 Phosphothreonine.
 MOD_RES 526 526 Phosphoserine.
 MOD_RES 531 531 Phosphothreonine.  
Keyword
 3D-structure; Cell cycle; Cell division; Complete proteome; Cytoplasm; Guanine-nucleotide releasing factor; Mitosis; Nucleus; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 547 AA 
Protein Sequence
MPRRKALTNN NNAGEAEQQP PKAKRARIAF HLELPKRRTV LGNVLVCGNG DVGQLGLGED 60
ILERKRLSPV AGIPDAVDIS AGGMHNLVLT KSGDIYSFGC NDEGALGRDT SEDGSESKPD 120
LIDLPGKALC ISAGDSHSAC LLEDGRVFAW GSFRDSHGNM GLTIDGNKRT PIDLMEGTVC 180
CSIASGADHL VILTTAGKVF TVGCAEQGQL GRLSERSISG EGRRGKRDLL RPTQLIITRA 240
KPFEAIWATN YCTFMRESQT QVIWATGLNN FKQLAHETKG KEFALTPIKT ELKDIRHIAG 300
GQHHTVILTT DLKCSVVGRP EYGRLGLGDV KDVVEKPTIV KKLTEKIVSV GCGEVCSYAV 360
TIDGKLYSWG SGVNNQLGVG DGDDELEPIV VVSKNTQGKH MLLASGGGQH AIFLVKADKQ 420
DQKENVPVKV SGSSSISKKD KTPPQDNVDK EAENVDKQEQ KENLPAKAST SSKKNKTPPQ 480
DNADKEAENV DKQEQKENLP AKASTSSKKI KTPPQDDAAE EVEEESAQEP TPKKAKKPAA 540
KRGGKKT 547 
Gene Ontology
 GO:0000793; C:condensed chromosome; IDA:FlyBase.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0003682; F:chromatin binding; IDA:UniProtKB.
 GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007417; P:central nervous system development; IDA:UniProtKB.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0006607; P:NLS-bearing substrate import into nucleus; IMP:FlyBase.
 GO:0007346; P:regulation of mitotic cell cycle; IDA:UniProtKB.
 GO:0050767; P:regulation of neurogenesis; IMP:FlyBase.
 GO:0046822; P:regulation of nucleocytoplasmic transport; IMP:FlyBase. 
Interpro
 IPR009091; RCC1/BLIP-II.
 IPR000408; Reg_chr_condens. 
Pfam
 PF00415; RCC1 
SMART
  
PROSITE
 PS00625; RCC1_1
 PS00626; RCC1_2
 PS50012; RCC1_3 
PRINTS
 PR00633; RCCNDNSATION.