UniProt Accession

 A5GZX3_MOUSE; A5GZX3 

Genbank Protein ID

 DQ487161; DQ487162; CH466542 

Genbank Nucleotide ID

 ABF48483.1; ABF48484.1; EDL08651.1 

Protein Name

 Glyoxalase 1 

Protein Synonyms/Alias

 Glyoxalase I 

Gene Name

 Glo1 

Gene Synonyms/Alias

 mCG_50439 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
60	LGLTLLQKLDFPAMK	ubiquitination	[1]
88	IPKDKSEKTAWTFSR	ubiquitination	[1]
96	TAWTFSRKATLELTH	ubiquitination	[1]
140	PDVYSACKRFEELGV	ubiquitination	[1]
148	RFEELGVKFVKKPDD	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

  

Sequence Annotation

  

Keyword

 Lyase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 184 AA 

Protein Sequence

Gene Ontology

 GO:0004462; F:lactoylglutathione lyase activity; IDA:MGI.
 GO:0046872; F:metal ion binding; IEA:InterPro.
 GO:0005975; P:carbohydrate metabolic process; IEA:Compara.
 GO:0006749; P:glutathione metabolic process; IEA:Compara.
 GO:0009438; P:methylglyoxal metabolic process; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IDA:MGI. 

Interpro

 IPR004360; Glyas_Fos-R_dOase_dom.
 IPR004361; Glyoxalase_1.
 IPR018146; Glyoxalase_1_CS. 

Pfam

 PF00903; Glyoxalase 

SMART

  

PROSITE

 PS00934; GLYOXALASE_I_1
 PS00935; GLYOXALASE_I_2 

PRINTS