UniProt Accession

 QUED_ECOLI; P65870; Q2MA64; Q46903 

Genbank Protein ID

 U29579; U00096; AP009048 

Genbank Nucleotide ID

 AAA69275.1; AAC75807.1; BAE76842.1 

Protein Name

 6-carboxy-5,6,7,8-tetrahydropterin synthase 

Protein Synonyms/Alias

 CPH4 synthase; Queuosine biosynthesis protein QueD 

Gene Name

 queD 

Gene Synonyms/Alias

 ygcM; b2765; JW2735 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
63	AELKAAFKPTYERLD	acetylation	[1, 2]

Reference

 [1] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111]
 [2] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde. Can also convert 6-pyruvoyltetrahydropterin (PPH4) and sepiapterin to CPH4; these 2 compounds are probably intermediates in the reaction from H2NTP. 

Sequence Annotation

 ACT_SITE 27 27 Proton acceptor (By similarity).
 ACT_SITE 71 71 Charge relay system (By similarity).
 ACT_SITE 110 110 Charge relay system (By similarity).
 METAL 16 16 Zinc (By similarity).
 METAL 31 31 Zinc (By similarity).
 METAL 33 33 Zinc (By similarity).  

Keyword

 3D-structure; Complete proteome; Lyase; Metal-binding; Queuosine biosynthesis; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 121 AA 

Protein Sequence

Gene Ontology

 GO:0070497; F:6-carboxy-5,6,7,8-tetrahydropterin synthase activity; IDA:EcoCyc.
 GO:0008270; F:zinc ion binding; IDA:EcoCyc.
 GO:0008616; P:queuosine biosynthetic process; IEA:UniProtKB-KW. 

Interpro

 IPR007115; 6-PTP_synth/QueD. 

Pfam

 PF01242; PTPS 

SMART

  

PROSITE

  

PRINTS