UniProt Accession

 HNRDL_HUMAN; O14979; Q6SPF2; Q7KZ74; Q7KZ75; Q96IM0; Q96S43 

Genbank Protein ID

 AB017019; D89092; AB066484; CR407623; AC124016; AB017018; AB017018; BC007392; BC011714; BC071944; AY453824; D89678 

Genbank Nucleotide ID

 BAA75241.1; BAA24361.1; BAB62188.1; CAG28551.1; AAY40914.1; BAA75239.1; BAA75240.1; AAH07392.2; AAH11714.1; AAH71944.1; AAR17782.1; BAA22860.1 

Protein Name

 Heterogeneous nuclear ribonucleoprotein D-like 

Protein Synonyms/Alias

 hnRNP D-like; hnRNP DL; AU-rich element RNA-binding factor; JKT41-binding protein; Protein laAUF1 

Gene Name

 HNRPDL 

Gene Synonyms/Alias

 JKTBP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
43	LSWDTSKKDLTEYLS	ubiquitination	[1]
78	GFGFVLFKDAASVDK	ubiquitination	[1, 2]
85	KDAASVDKVLELKEH	ubiquitination	[1]
115	KGKEPPKKVFVGGLS	ubiquitination	[1]
150	IELPMDTKTNERRGF	ubiquitination	[2]
183	YHQIGSGKCEIKVAQ	ubiquitination	[1]
192	EIKVAQPKEVYRQQQ	ubiquitination	[1]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes (By similarity). Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter (By similarity). Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence. 

Sequence Annotation

 DOMAIN 148 230 RRM 1.
 DOMAIN 233 312 RRM 2.
 REGION 342 420 Necessary for interaction with TNPO1.
 REGION 396 420 Necessary for its nuclear import and
 MOD_RES 161 161 N6-methyllysine.
 MOD_RES 216 216 N6-acetyllysine.
 MOD_RES 241 241 Phosphoserine.
 MOD_RES 408 408 Dimethylated arginine.  

Keyword

 Acetylation; Activator; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; DNA-binding; Methylation; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; RNA-binding; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 420 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005681; C:spliceosomal complex; NAS:UniProtKB.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003690; F:double-stranded DNA binding; IDA:UniProtKB.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0008143; F:poly(A) RNA binding; IDA:UniProtKB.
 GO:0034046; F:poly(G) RNA binding; IDA:UniProtKB.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0003697; F:single-stranded DNA binding; IDA:UniProtKB.
 GO:0010468; P:regulation of gene expression; IDA:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006396; P:RNA processing; NAS:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS