UniProt Accession

 GMDS_MOUSE; Q8K0C9 

Genbank Protein ID

 AL645643; AL645664; AL645697; AL645783; AL645763; AL645664; AL645643; AL645697; AL645783; AL645763; AL645697; AL645643; AL645664; AL645783; AL645763; AL645763; AL645643; AL645664; AL645697; AL645783; AL645783; AL645643; AL645664; AL645697; AL645763; BC031788; BC093502 

Genbank Nucleotide ID

 CAI24766.1; CAI24766.1; CAI24766.1; CAI24766.1; CAI24766.1; CAI25621.1; CAI25621.1; CAI25621.1; CAI25621.1; CAI25621.1; CAI24852.1; CAI24852.1; CAI24852.1; CAI24852.1; CAI24852.1; CAI24125.1; CAI24125.1; CAI24125.1; CAI24125.1; CAI24125.1; CAI25768.1; CAI25768.1; CAI25768.1; CAI25768.1; CAI25768.1; AAH31788.1; AAH93502.1 

Protein Name

 GDP-mannose 4,6 dehydratase 

Protein Synonyms/Alias

 GDP-D-mannose dehydratase; GMD 

Gene Name

 Gmds 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
140	LRLLDAIKTCGLINS	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose (By similarity). 

Sequence Annotation

 NP_BIND 30 35 NADP (By similarity).
 NP_BIND 86 87 NADP (By similarity).
 NP_BIND 108 112 NADP (By similarity).
 ACT_SITE 155 155 By similarity.
 ACT_SITE 157 157 Nucleophile (By similarity).
 ACT_SITE 179 179 Nucleophile (By similarity).
 BINDING 123 123 NADP (By similarity).
 BINDING 183 183 NADP (By similarity).
 BINDING 209 209 NADP (By similarity).
 BINDING 214 214 NADP (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).  

Keyword

 Acetylation; Complete proteome; Lyase; NADP; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 372 AA 

Protein Sequence

Gene Ontology

 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0008446; F:GDP-mannose 4,6-dehydratase activity; ISS:UniProtKB.
 GO:0070401; F:NADP+ binding; ISS:UniProtKB.
 GO:0042351; P:'de novo' GDP-L-fucose biosynthetic process; ISS:UniProtKB.
 GO:0019673; P:GDP-mannose metabolic process; ISS:UniProtKB.
 GO:0007219; P:Notch signaling pathway; ISS:UniProtKB. 

Interpro

 IPR001509; Epimerase_deHydtase.
 IPR006368; GDP_Man_deHydtase.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF01370; Epimerase 

SMART

  

PROSITE

  

PRINTS