CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011774
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Homocitrate synthase, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 LYS21 
Gene Synonyms/Alias
 YDL131W; D2195 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
414ELSTPLLKPVNKGTDacetylation[1]
434ISNGHVSKKAKVTK*acetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919
Functional Description
  
Sequence Annotation
 MOD_RES 410 410 Phosphothreonine.  
Keyword
 Amino-acid biosynthesis; Complete proteome; Lysine biosynthesis; Mitochondrion; Phosphoprotein; Reference proteome; Transferase; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 440 AA 
Protein Sequence
MSENNEFQSV TESTTAPTTS NPYGPNPADY LSNVKNFQLI DSTLREGEQF ANAFFDTEKK 60
IEIARALDDF GVDYIELTSP VASEQSRKDC EAICKLGLKA KILTHIRCHM DDARVAVETG 120
VDGVDVVIGT SKFLRQYSHG KDMNYIAKSA VEVIEFVKSK GIEIRFSSED SFRSDLVDLL 180
NIYKTVDKIG VNRVGIADTV GCANPRQVYE LIRTLKSVVS CDIECHFHND TGCAIANAYT 240
ALEGGARLID VSVLGIGERN GITPLGGLMA RMIVAAPDYV RSKYKLHKIR DIENLVADAV 300
EVNIPFNNPI TGFCAFTHKA GIHAKAILAN PSTYEILDPH DFGMKRYIHF ANRLTGWNAI 360
KSRVDQLNLN LTDDQIKEVT AKIKKLGDVR PLNIDDVDSI IKDFHAELST PLLKPVNKGT 420
DDDNIDISNG HVSKKAKVTK 440 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0004410; F:homocitrate synthase activity; ISS:SGD.
 GO:0019878; P:lysine biosynthetic process via aminoadipic acid; IMP:SGD. 
Interpro
 IPR002034; AIPM/Hcit_synth_CS.
 IPR013785; Aldolase_TIM.
 IPR011872; Homocitrate_synth_fun/arc.
 IPR000891; PYR_CT. 
Pfam
 PF00682; HMGL-like 
SMART
  
PROSITE
 PS00815; AIPM_HOMOCIT_SYNTH_1
 PS00816; AIPM_HOMOCIT_SYNTH_2
 PS50991; PYR_CT 
PRINTS