UniProt Accession

 CDCA5_HUMAN; Q96FF9; A8K625 

Genbank Protein ID

 BG354578; AK291490; CH471076; BC011000 

Genbank Nucleotide ID

 BAF84179.1; EAW74342.1; AAH11000.1 

Protein Name

 Sororin 

Protein Synonyms/Alias

 Cell division cycle-associated protein 5; p35 

Gene Name

 CDCA5 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
99	PPGRELTKEDLFKTH	ubiquitination	[1]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPAL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair. 

Sequence Annotation

 MOTIF 88 90 KEN box.
 MOTIF 166 168 FGF motif.
 MOD_RES 21 21 Phosphoserine.
 MOD_RES 33 33 Phosphoserine.
 MOD_RES 35 35 Phosphoserine.
 MOD_RES 75 75 Phosphoserine.
 MOD_RES 79 79 Phosphoserine.
 MOD_RES 107 107 Phosphoserine.
 MOD_RES 115 115 Phosphothreonine.
 MOD_RES 209 209 Phosphoserine.  

Keyword

 Cell cycle; Cell division; Chromosome; Complete proteome; Cytoplasm; Mitosis; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 252 AA 

Protein Sequence

Gene Ontology

 GO:0000775; C:chromosome, centromeric region; TAS:Reactome.
 GO:0008278; C:cohesin complex; IEA:Compara.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0000790; C:nuclear chromatin; ISS:UniProtKB.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0003682; F:chromatin binding; TAS:UniProtKB.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0006302; P:double-strand break repair; IMP:UniProtKB.
 GO:0000082; P:G1/S transition of mitotic cell cycle; IDA:UniProtKB.
 GO:0007076; P:mitotic chromosome condensation; IMP:UniProtKB.
 GO:0007080; P:mitotic metaphase plate congression; IMP:UniProtKB.
 GO:0007064; P:mitotic sister chromatid cohesion; IMP:UniProtKB.
 GO:0071922; P:regulation of cohesin localization to chromatin; IMP:UniProtKB. 

Interpro

 IPR018605; Sororin. 

Pfam

 PF09666; Sororin 

SMART

  

PROSITE

  

PRINTS