CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024755
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cell invasion protein SipC 
Protein Synonyms/Alias
 Effector protein SipC 
Gene Name
 sipC 
Gene Synonyms/Alias
 sspC; SL1344_2863 
Created Date
 July 27, 2013 
Organism
 Salmonella typhimurium (strain SL1344) 
NCBI Taxa ID
 216597 
Lysine Modification
Position
Peptide
Type
References
197VGAKLEYKGLQNERGacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Actin-binding protein that interferes with host cell actin cytoskeleton. Nucleates actin polymerization and condensates actin filaments into cables (bundling). SipA potenciates SipC activity and both are required for an efficient bacterial internalization by the host cell (By similarity). 
Sequence Annotation
 REGION 1 119 Actin-bundling.
 REGION 120 200 Inserted into the host cell plasma
 REGION 201 409 Actin-polymerization.  
Keyword
 Actin-binding; Complete proteome; Secreted; Virulence. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 409 AA 
Protein Sequence
MLISNVGINP AAYLNNHSVE NSSQTASQSV SAKDILNSIG ISSSKVSDLG LSPTLSAPAP 60
GVLTQTPGTI TSFLKASIQN TDMNQDLNAL ANNVTTKANE VVQTQLREQQ AEVGKFFDIS 120
GMSSSAVALL AAANTLMLTL NQADSKLSGK LSLVSFDAAK TTASSMMREG MNALSGSISQ 180
SALQLGITGV GAKLEYKGLQ NERGALKHNA AKIDKLTTES HSIKNVLNGQ NSVKLGAEGV 240
DSLKSLNMKK TGTDATKNLN DATLKSNAGT SATESLGIKD SNKQISPEHQ AILSKRLESV 300
ESDIRLEQNT MDMTRIDARK MQMTGDLIMK NSVTVGGIAG ASGQYAATQE RSEQQISQVN 360
NRVASTASDE ARESSRKSTS LIQEMLKTME SINQSKASAL AAIAGNIRA 409 
Gene Ontology
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0009405; P:pathogenesis; IEA:UniProtKB-KW. 
Interpro
 IPR005427; BacInvasinC. 
Pfam
 PF09599; IpaC_SipC 
SMART
  
PROSITE
  
PRINTS
 PR01608; BACINVASINC.