UniProt Accession

 B4DGX2_HUMAN; B4DGX2 

Genbank Protein ID

 AL157707; AL390318; AL513128; AK294817 

Genbank Nucleotide ID

 BAG57933.1 

Protein Name

 Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha 

Protein Synonyms/Alias

 cDNA FLJ53867, highly similar to Phosphatidylinositol-4-phosphate 5-kinase type-2 alpha (EC 2.7.1.68) 

Gene Name

 PIP4K2A 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
32	MPSHFKFKEYCPMVF	ubiquitination	[1]
154	VYRKYDLKGSTVARE	ubiquitination	[1]
193	IYIDDNNKKVFLEKL	ubiquitination	[1]
199	NKKVFLEKLKKDVEF	ubiquitination	[1]
201	KVFLEKLKKDVEFLA	ubiquitination	[1]
336	VNPEQYSKRFLDFIG	ubiquitination	[2, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Kinase; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 347 AA 

Protein Sequence

Gene Ontology

 GO:0016307; F:phosphatidylinositol phosphate kinase activity; IEA:InterPro.
 GO:0035855; P:megakaryocyte development; IEA:Compara.
 GO:0046854; P:phosphatidylinositol phosphorylation; IEA:GOC. 

Interpro

 IPR023610; PInositol-4-P-5-kinase.
 IPR027483; PInositol-4-P-5-kinase_C.
 IPR002498; PInositol-4-P-5-kinase_core.
 IPR027484; PInositol-4-P-5-kinase_N.
 IPR016034; PInositol-4P-5-kinase_core_sub. 

Pfam

 PF01504; PIP5K 

SMART

 SM00330; PIPKc 

PROSITE

 PS51455; PIPK 

PRINTS