| Tag | Content |
|---|
| CPLM ID | CPLM-003065 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | tRNA (guanine-N(1)-)-methyltransferase |
Protein Synonyms/Alias | M1G-methyltransferase; tRNA [GM37] methyltransferase |
Gene Name | trmD |
Gene Synonyms/Alias | b2607; JW2588 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 241 | ARLLAEFKTEHAQQQ | acetylation | [1] | | 250 | EHAQQQHKHDGMA** | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Specifically methylates guanosine-37 in various tRNAs. |
Sequence Annotation | REGION 133 138 S-adenosyl-L-methionine binding.
ACT_SITE 169 169 Proton acceptor (Potential).
BINDING 86 86 S-adenosyl-L-methionine.
BINDING 113 113 S-adenosyl-L-methionine; via amide |
Keyword | 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Methyltransferase; Reference proteome; S-adenosyl-L-methionine; Transferase; tRNA processing. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 255 AA |
Protein Sequence | MWIGIISLFP EMFRAITDYG VTGRAVKNGL LSIQSWSPRD FTHDRHRTVD DRPYGGGPGM 60
LMMVQPLRDA IHAAKAAAGE GAKVIYLSPQ GRKLDQAGVS ELATNQKLIL VCGRYEGIDE 120
RVIQTEIDEE WSIGDYVLSG GELPAMTLID SVSRFIPGVL GHEASATEDS FAEGLLDCPH 180
YTRPEVLEGM EVPPVLLSGN HAEIRRWRLK QSLGRTWLRR PELLENLALT EEQARLLAEF 240
KTEHAQQQHK HDGMA 255 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0003723; F:RNA binding; IEA:InterPro. GO:0052906; F:tRNA (guanine(37)-N(1))-methyltransferase activity; IEA:EC. GO:0009019; F:tRNA (guanine-N1-)-methyltransferase activity; IDA:EcoCyc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |