UniProt Accession

 C9IZW4_HUMAN; C9IZW4 

Genbank Protein ID

 AC060780; AC135721 

Genbank Nucleotide ID

  

Protein Name

 Breast cancer type 1 susceptibility protein 

Protein Synonyms/Alias

  

Gene Name

 BRCA1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
154	KSERVHSKSVESNIE	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 177 AA 

Protein Sequence

Gene Ontology

 GO:0000794; C:condensed nuclear chromosome; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0003684; F:damaged DNA binding; IEA:Compara.
 GO:0044212; F:transcription regulatory region DNA binding; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0007098; P:centrosome cycle; IEA:Compara.
 GO:0043009; P:chordate embryonic development; IEA:Compara.
 GO:0006281; P:DNA repair; IEA:InterPro.
 GO:0006260; P:DNA replication; IEA:Compara.
 GO:0009048; P:dosage compensation by inactivation of X chromosome; IEA:Compara.
 GO:0035067; P:negative regulation of histone acetylation; IEA:Compara.
 GO:0051572; P:negative regulation of histone H3-K4 methylation; IEA:Compara.
 GO:0051573; P:negative regulation of histone H3-K9 methylation; IEA:Compara.
 GO:0051571; P:positive regulation of histone H3-K4 methylation; IEA:Compara.
 GO:2000617; P:positive regulation of histone H3-K9 acetylation; IEA:Compara.
 GO:0051574; P:positive regulation of histone H3-K9 methylation; IEA:Compara.
 GO:2000620; P:positive regulation of histone H4-K16 acetylation; IEA:Compara.
 GO:0070512; P:positive regulation of histone H4-K20 methylation; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0044030; P:regulation of DNA methylation; IEA:Compara.
 GO:0006349; P:regulation of gene expression by genetic imprinting; IEA:Compara. 

Interpro

 IPR011364; BRCA1.
 IPR025994; BRCA1_serine_dom. 

Pfam

 PF12820; BRCT_assoc 

SMART

  

PROSITE

  

PRINTS