UniProt Accession

 YO283_YEAST; Q12040; D6W2Y1 

Genbank Protein ID

 X89633; Z75191; BK006948 

Genbank Nucleotide ID

 CAA61787.1; CAA99510.1; DAA11047.1 

Protein Name

 Broad-specificity phosphatase YOR283W 

Protein Synonyms/Alias

  

Gene Name

 YOR283W 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
88	ALVLKHSKQENVPTS	acetylation	[1]
122	EAEKYADKHGEGSFR	acetylation	[1]
159	EASNEGVKNLALVSH	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Metal-independent phosphatase active against a broad range of phosphorylated substrates including nucleoside tri- and diphosphates, phosphorylated organic acids, and amino acids. Shows no activity against phytic acid, phosphorylated carbohydrates, and nucleoside monophosphates. 

Sequence Annotation

 REGION 36 37 Substrate binding (By similarity).
 REGION 102 105 Substrate binding (By similarity).
 ACT_SITE 24 24 Tele-phosphohistidine intermediate (By
 ACT_SITE 166 166 By similarity.
 BINDING 30 30 Substrate (By similarity).
 BINDING 75 75 Substrate (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Hydrolase; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 230 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0016791; F:phosphatase activity; IDA:SGD. 

Interpro

 IPR013078; His_Pase_superF_clade-1.
 IPR001345; PG/BPGM_mutase_AS. 

Pfam

 PF00300; His_Phos_1 

SMART

 SM00855; PGAM 

PROSITE

 PS00175; PG_MUTASE 

PRINTS