UniProt Accession

 RSC9_YEAST; Q03124; D6W0F8 

Genbank Protein ID

 Z50178; BK006946 

Genbank Nucleotide ID

 CAA90556.1; DAA09772.1 

Protein Name

 Chromatin structure-remodeling complex subunit RSC9 

Protein Synonyms/Alias

 RSC complex subunit RSC9; Remodel the structure of chromatin complex subunit 9 

Gene Name

 RSC9 

Gene Synonyms/Alias

 YML127W; YM4987.08 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
434	PVRESGRKLLPAVEF	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit plays a role in transcriptional response to stress. It is involved in both repression and activation of mRNAs regulated by the target of rapamycin (TOR) kinases, and in the synthesis of rRNA. 

Sequence Annotation

 DNA_BIND 395 476 RFX-type winged-helix.
 MOD_RES 44 44 Phosphoserine.  

Keyword

 Chromatin regulator; Complete proteome; Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome; rRNA processing; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 581 AA 

Protein Sequence

Gene Ontology

 GO:0016586; C:RSC complex; IDA:UniProtKB.
 GO:0003682; F:chromatin binding; IPI:SGD.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0043044; P:ATP-dependent chromatin remodeling; IDA:UniProtKB.
 GO:0000086; P:G2/M transition of mitotic cell cycle; IMP:SGD.
 GO:0006337; P:nucleosome disassembly; IDA:SGD.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IMP:SGD.
 GO:0006950; P:response to stress; IDA:UniProtKB.
 GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
 GO:0009303; P:rRNA transcription; IMP:UniProtKB.
 GO:0006368; P:transcription elongation from RNA polymerase II promoter; IDA:SGD. 

Interpro

 IPR003150; DNA-bd_RFX. 

Pfam

  

SMART

  

PROSITE

 PS51526; RFX_DBD 

PRINTS