| Tag | Content |
|---|
| CPLM ID | CPLM-014569 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | KN motif and ankyrin repeat domain-containing protein 2 |
Protein Synonyms/Alias | Ankyrin repeat domain-containing protein 25; Matrix-remodeling-associated protein 3; SRC-1-interacting protein; SIP; SRC-interacting protein; SRC1-interacting protein |
Gene Name | KANK2 |
Gene Synonyms/Alias | ANKRD25; KIAA1518; MXRA3; SIP |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 223 | LSVLQEEKRQLTVQL | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase- independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus. May be involved in promotion of cell proliferation. |
Sequence Annotation | REPEAT 666 696 ANK 1.
REPEAT 700 733 ANK 2.
REPEAT 738 767 ANK 3.
REPEAT 771 801 ANK 4.
REPEAT 805 835 ANK 5.
REGION 1 72 Interaction with AIFM1.
REGION 669 835 Interaction with NCOA1.
MOD_RES 19 19 Phosphoserine.
MOD_RES 246 246 Phosphoserine (By similarity).
MOD_RES 356 356 Phosphoserine.
MOD_RES 375 375 Phosphoserine.
MOD_RES 472 472 Phosphothreonine. |
Keyword | 3D-structure; Alternative splicing; ANK repeat; Apoptosis; Coiled coil; Complete proteome; Cytoplasm; Mitochondrion; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 851 AA |
Protein Sequence | MAQVLHVPAP FPGTPGPASP PAFPAKDPDP PYSVETPYGY RLDLDFLKYV DDIEKGHTLR 60
RVAVQRRPRL SSLPRGPGSW WTSTESLCSN ASGDSRHSAY SYCGRGFYPQ YGALETRGGF 120
NPRVERTLLD ARRRLEDQAA TPTGLGSLTP SAAGSTASLV GVGLPPPTPR SSGLSTPVPP 180
SAGHLAHVRE QMAGALRKLR QLEEQVKLIP VLQVKLSVLQ EEKRQLTVQL KSQKFLGHPT 240
AGRGRSELCL DLPDPPEDPV ALETRSVGTW VRERDLGMPD GEAALAAKVA VLETQLKKAL 300
QELQAAQARQ ADPQPQAWPP PDSPVRVDTV RVVEGPREVE VVASTAAGAP AQRAQSLEPY 360
GTGLRALAMP GRPESPPVFR SQEVVETMCP VPAAATSNVH MVKKISITER SCDGAAGLPE 420
VPAESSSSPP GSEVASLTQP EKSTGRVPTQ EPTHREPTRQ AASQESEEAG GTAPPLSSPP 480
GGPPAGVRSI MKRKEEVADP TAHRRSLQFV GVNGGYESSS EDSSTAENIS DNDSTENEAP 540
EPRERVPSVA EAPQLRPAGT AAAKTSRQEC QLSRESQHIP TAEGASGSNT EEEIRMELSP 600
DLISACLALE KYLDNPNALT ERELKVAYTT VLQEWLRLAC RSDAHPELVR RHLVTFRAMS 660
ARLLDYVVNI ADSNGNTALH YSVSHANFPV VQQLLDSGVC KVDKQNRAGY SPIMLTALAT 720
LKTQDDIETV LQLFRLGNIN AKASQAGQTA LMLAVSHGRV DVVKALLACE ADVNVQDDDG 780
STALMCACEH GHKEIAGLLL AVPSCDISLT DRDGSTALMV ALDAGQSEIA SMLYSRMNIK 840
CSFAPMSDDE SPTSSSAEE 859 |
Gene Ontology | GO:0005739; C:mitochondrion; IDA:UniProtKB. GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. GO:0008285; P:negative regulation of cell proliferation; IDA:UniProtKB. GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; IDA:UniProtKB. GO:0033147; P:negative regulation of intracellular estrogen receptor signaling pathway; IDA:UniProtKB. GO:0043069; P:negative regulation of programmed cell death; IDA:UniProtKB. GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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