| Tag | Content |
|---|
| CPLM ID | CPLM-017745 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein NEDD1 |
Protein Synonyms/Alias | Neural precursor cell expressed developmentally down-regulated protein 1; NEDD-1 |
Gene Name | NEDD1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 243 | TSSKKLVKTLVADTP | ubiquitination | [1] | | 391 | SKETDSGKNQDFSSF | ubiquitination | [1] | | 570 | VASSLSEKIADSIGN | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. |
Sequence Annotation | REPEAT 1 31 WD 1.
REPEAT 32 71 WD 2.
REPEAT 75 114 WD 3.
REPEAT 117 156 WD 4.
REPEAT 160 200 WD 5.
REPEAT 204 244 WD 6.
REPEAT 246 285 WD 7.
REPEAT 289 332 WD 8.
MOD_RES 382 382 Phosphothreonine; by PLK1.
MOD_RES 397 397 Phosphoserine; by PLK1.
MOD_RES 411 411 Phosphoserine.
MOD_RES 426 426 Phosphoserine; by PLK1.
MOD_RES 516 516 Phosphoserine.
MOD_RES 550 550 Phosphothreonine; by CDK1.
MOD_RES 637 637 Phosphoserine; by PLK1. |
Keyword | Alternative splicing; Cell cycle; Cell division; Complete proteome; Cytoplasm; Cytoskeleton; Mitosis; Phosphoprotein; Reference proteome; Repeat; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 660 AA |
Protein Sequence | MQENLRFASS GDDIKIWDAS SMTLVDKFNP HTSPHGISSI CWSSNNNFLV TASSSGDKIV 60
VSSCKCKPVP LLELAEGQKQ TCVNLNSTSM YLVSGGLNNT VNIWDLKSKR VHRSLKDHKD 120
QVTCVTYNWN DCYIASGSLS GEIILHSVTT NLSSTPFGHG SNQSVRHLKY SLFKKSLLGS 180
VSDNGIVTLW DVNSQSPYHN FDSVHKAPAS GICFSPVNEL LFVTIGLDKR IILYDTSSKK 240
LVKTLVADTP LTAVDFMPDG ATLAIGSSRG KIYQYDLRML KSPVKTISAH KTSVQCIAFQ 300
YSTVLTKSSL NKGCSNKPTT VNKRSVNVNA ASGGVQNSGI VREAPATSIA TVLPQPMTSA 360
MGKGTVAVQE KAGLPRSINT DTLSKETDSG KNQDFSSFDD TGKSSLGDMF SPIRDDAVVN 420
KGSDESIGKG DGFDFLPQLN SVFPPRKNPV TSSTSVLHSS PLNVFMGSPG KEENENRDLT 480
AESKKIYMGK QESKDSFKQL AKLVTSGAES GNLNTSPSSN QTRNSEKFEK PENEIEAQLI 540
CEPPINGSST PNPKIASSVT AGVASSLSEK IADSIGNNRQ NAPLTSIQIR FIQNMIQETL 600
DDFREACHRD IVNLQVEMIK QFHMQLNEMH SLLERYSVNE GLVAEIERLR EENKRLRAHF 660 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |