CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011784
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sister chromatid cohesion protein 1 
Protein Synonyms/Alias
  
Gene Name
 MCD1 
Gene Synonyms/Alias
 PDS3; RHC21; SCC1; YDL003W; YD8119.04 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
52ESAKEIAKASGCDDEubiquitination[1]
109MLFKTSQKMTSTVNRubiquitination[1]
165QENSMERKVQGAAPWsumoylation[2]
290GFDLDIEKEAPAGNIsumoylation[2]
460EENIIDAKTRNEQTTsumoylation[2]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] SUMOylation of the α-kleisin subunit of cohesin is required for DNA damage-induced cohesion.
 McAleenan A, Cordon-Preciado V, Clemente-Blanco A, Liu IC, Sen N, Leonard J, Jarmuz A, Aragón L.
 Curr Biol. 2012 Sep 11;22(17):1564-75. [PMID: 22771042] 
Functional Description
 Cleavable component of the cohesin complex involved in chromosome cohesion during cell cycle. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by ESP1 and dissociates from chromatin, allowing sister chromatids to segregate. 
Sequence Annotation
 MOD_RES 161 161 Phosphoserine.
 MOD_RES 175 175 Phosphoserine; by CDC5.
 MOD_RES 210 210 N6-acetyllysine; by ECO1.
 MOD_RES 263 263 Phosphoserine; by CDC5.
 MOD_RES 307 307 Phosphoserine.
 MOD_RES 354 354 Phosphothreonine.  
Keyword
 3D-structure; Acetylation; Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition; Complete proteome; Mitosis; Nucleus; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 566 AA 
Protein Sequence
MVTENPQRLT VLRLATNKGP LAQIWLASNM SNIPRGSVIQ THIAESAKEI AKASGCDDES 60
GDNEYITLRT SGELLQGIVR VYSKQATFLL TDIKDTLTKI SMLFKTSQKM TSTVNRLNTV 120
TRVHQLMLED AVTEREVLVT PGLEFLDDTT IPVGLMAQEN SMERKVQGAA PWDTSLEVGR 180
RFSPDEDFEH NNLSSMNLDF DIEEGPITSK SWEEGTRQSS RNFDTHENYI QDDDFPLDDA 240
GTIGWDLGIT EKNDQNNDDD DNSVEQGRRL GESIMSEEPT DFGFDLDIEK EAPAGNIDTI 300
TDAMTESQPK QTGTRRNSKL LNTKSIQIDE ETENSESIAS SNTYKEERSN NLLTPQPTNF 360
TTKRLWSEIT ESMSYLPDPI LKNFLSYESL KKRKIHNGRE GSIEEPELNV SLNLTDDVIS 420
NAGTNDNSFN ELTDNMSDFV PIDAGLNEAP FPEENIIDAK TRNEQTTIQT EKVRPTPGEV 480
ASKAIVQMAK ILRKELSEEK EVIFTDVLKS QANTEPENIT KREASRGFFD ILSLATEGCI 540
GLSQTEAFGN IKIDAKPALF ERFINA 566 
Gene Ontology
 GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:SGD.
 GO:0034990; C:nuclear mitotic cohesin complex; IDA:SGD.
 GO:0003682; F:chromatin binding; IDA:SGD.
 GO:0006915; P:apoptotic process; IMP:SGD.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0006302; P:double-strand break repair; IMP:SGD.
 GO:0034087; P:establishment of mitotic sister chromatid cohesion; IMP:SGD.
 GO:0007076; P:mitotic chromosome condensation; IMP:SGD.
 GO:0006473; P:protein acetylation; IDA:UniProtKB. 
Interpro
 IPR023093; Rad21/Rec8_C.
 IPR006909; Rad21/Rec8_C_eu.
 IPR006910; Rad21_Rec8_N. 
Pfam
 PF04824; Rad21_Rec8
 PF04825; Rad21_Rec8_N 
SMART
  
PROSITE
  
PRINTS