UniProt Accession

 RCN2_HUMAN; Q14257; A8MTG6; Q53XN8 

Genbank Protein ID

 X78669; BT009790; AK313833; AC051643; BC004892 

Genbank Nucleotide ID

 CAA55343.1; AAP88792.1; BAG36566.1; AAH04892.1 

Protein Name

 Reticulocalbin-2 

Protein Synonyms/Alias

 Calcium-binding protein ERC-55; E6-binding protein; E6BP 

Gene Name

 RCN2 

Gene Synonyms/Alias

 ERC55 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
56	EDVDEYVKLGHEEQQ	ubiquitination	[1]
64	LGHEEQQKRLQAIIK	ubiquitination	[1]
103	HYAMQEAKQQFVEYD	ubiquitination	[1, 2, 3]
232	PEWILVEKDRFVNDY	ubiquitination	[1, 2, 3]
282	MDLNGDKKLSEEEIL	ubiquitination	[2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Not known. Binds calcium. 

Sequence Annotation

 DOMAIN 61 96 EF-hand 1.
 DOMAIN 97 132 EF-hand 2.
 DOMAIN 150 185 EF-hand 3.
 DOMAIN 186 221 EF-hand 4.
 DOMAIN 227 262 EF-hand 5.
 DOMAIN 263 298 EF-hand 6.
 MOTIF 314 317 Prevents secretion from ER (Potential).  

Keyword

 Calcium; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Metal-binding; Reference proteome; Repeat; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 317 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; TAS:ProtInc.
 GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
 GO:0005509; F:calcium ion binding; TAS:ProtInc. 

Interpro

 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom. 

Pfam

 PF13202; EF_hand_3
 PF13499; EF_hand_5 

SMART

 SM00054; EFh 

PROSITE

 PS00018; EF_HAND_1
 PS50222; EF_HAND_2
 PS00014; ER_TARGET 

PRINTS