CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003315
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 1,4-Dihydroxy-2-naphthoyl-CoA synthase 
Protein Synonyms/Alias
 DHNA-CoA synthase 
Gene Name
 menB 
Gene Synonyms/Alias
 b2262; JW2257 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
54AFRPLTVKEMIQALAacetylation[1]
80ILTGAGDKAFCSGGDacetylation[1]
89FCSGGDQKVRGDYGGacetylation[1]
98RGDYGGYKDDSGVHHacetylation[1]
193LCRQYDAKQALDMGLacetylation[1]
212VPLADLEKETVRWCRacetylation[1]
273GRNAFNQKRQPDFSKacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA). 
Sequence Annotation
 REGION 44 45 Substrate binding (By similarity).
 REGION 84 88 Substrate binding (By similarity).
 REGION 129 133 Substrate binding (By similarity).
 REGION 154 156 Bicarbonate binding (By similarity).
 BINDING 80 80 Substrate (By similarity).
 BINDING 155 155 Substrate (By similarity).
 BINDING 161 161 Substrate (By similarity).  
Keyword
 3D-structure; Complete proteome; Lyase; Menaquinone biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 285 AA 
Protein Sequence
MIYPDEAMLY APVEWHDCSE GFEDIRYEKS TDGIAKITIN RPQVRNAFRP LTVKEMIQAL 60
ADARYDDNIG VIILTGAGDK AFCSGGDQKV RGDYGGYKDD SGVHHLNVLD FQRQIRTCPK 120
PVVAMVAGYS IGGGHVLHMM CDLTIAADNA IFGQTGPKVG SFDGGWGASY MARIVGQKKA 180
REIWFLCRQY DAKQALDMGL VNTVVPLADL EKETVRWCRE MLQNSPMALR CLKAALNADC 240
DGQAGLQELA GNATMLFYMT EEGQEGRNAF NQKRQPDFSK FKRNP 285 
Gene Ontology
 GO:0008935; F:1,4-dihydroxy-2-naphthoyl-CoA synthase activity; IDA:EcoCyc.
 GO:0071890; F:bicarbonate binding; IDA:UniProtKB.
 GO:0009234; P:menaquinone biosynthetic process; IMP:EcoCyc. 
Interpro
 IPR014748; Crontonase_C.
 IPR001753; Crotonase_core_superfam.
 IPR018376; Enoyl-CoA_hyd/isom_CS.
 IPR010198; Naphthoate_synthase. 
Pfam
 PF00378; ECH 
SMART
  
PROSITE
 PS00166; ENOYL_COA_HYDRATASE 
PRINTS