CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015649
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Elongation factor 1-alpha 2 
Protein Synonyms/Alias
 EF-1-alpha-2; Eukaryotic elongation factor 1 A-2; eEF1A-2; Statin-S1 
Gene Name
 EEF1A2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Oryctolagus cuniculus (Rabbit) 
NCBI Taxa ID
 9986 
Lysine Modification
Position
Peptide
Type
References
55EMGKGSFKYAWVLDKmethylation[1]
165TEPAYSEKRYDEIVKmethylation[1]
Reference
 [1] Update on activities at the Universal Protein Resource (UniProt) in 2013.
 e="String">UniProt Consortium.
 Nucleic Acids Res. 2013 Jan;41(Database issue):D43-7. [PMID: 23161681] 
Functional Description
 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. 
Sequence Annotation
 NP_BIND 14 21 GTP (By similarity).
 NP_BIND 91 95 GTP (By similarity).
 NP_BIND 153 156 GTP (By similarity).
 MOD_RES 29 29 Phosphotyrosine (By similarity).
 MOD_RES 55 55 N6,N6,N6-trimethyllysine.
 MOD_RES 141 141 Phosphotyrosine (By similarity).
 MOD_RES 165 165 N6,N6,N6-trimethyllysine.
 MOD_RES 179 179 N6-acetyllysine (By similarity).
 MOD_RES 301 301 5-glutamyl
 MOD_RES 374 374 5-glutamyl
 MOD_RES 439 439 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Complete proteome; Direct protein sequencing; Elongation factor; GTP-binding; Methylation; Nucleotide-binding; Nucleus; Phosphoprotein; Protein biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 463 AA 
Protein Sequence
MGKEKTHINI VVIGHVDSGK STTTGHLIYK CGGIDKRTIE KFEKEAAEMG KGSFKYAWVL 60
DKLKAERERG ITIDISLWKF ETTKYYITII DAPGHRDFIK NMITGTSQAD CAVLIVAAGV 120
GEFEAGISKN GQTREHALLA YTLGVKQLIV GVNKMDSTEP AYSEKRYDEI VKEVSAYIKK 180
IGYNPATVPF VPISGWHGDN MLEPSPNMPW FKGWKVERKE GNASGVSLLE ALDTILPPTR 240
PTDKPLRLPL QDVYKIGGIG TVPVGRVETG ILRPGMVVTF APVNITTEVK SVEMHHEALS 300
EALPGDNVGF NVKNVSVKDI RRGNVCGDSK SDPPQEAAQF TSQVIILNHP GQISAGYSPV 360
IDCHTAHIAC KFAELKEKID RRSGKKLEDN PKSLKSGDAA IVEMVPGKPM CVESFSQYPP 420
LGRFAVRDMR QTVAVGVIKN VEKKSGGAGK VTKSAQKAQK AGK 463 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
 GO:0006184; P:GTP catabolic process; IEA:GOC. 
Interpro
 IPR000795; EF_GTP-bd_dom.
 IPR027417; P-loop_NTPase.
 IPR009001; Transl_elong_EF1A/Init_IF2_C.
 IPR004539; Transl_elong_EF1A_euk/arc.
 IPR004161; Transl_elong_EFTu/EF1A_2.
 IPR004160; Transl_elong_EFTu/EF1A_C.
 IPR009000; Transl_elong_init/rib_B-barrel. 
Pfam
 PF00009; GTP_EFTU
 PF03144; GTP_EFTU_D2
 PF03143; GTP_EFTU_D3 
SMART
  
PROSITE
 PS00301; EFACTOR_GTP 
PRINTS
 PR00315; ELONGATNFCT.