CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015376
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mastermind-like protein 1 
Protein Synonyms/Alias
 Mam-1 
Gene Name
 Maml1 
Gene Synonyms/Alias
 Kiaa0200 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
827TLPPGLTKPQVPRVSacetylation[1, 2]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. 
Sequence Annotation
 REGION 1 97 Required for interaction with NOTCH
 MOD_RES 127 127 Phosphoserine.
 MOD_RES 321 321 Phosphoserine (By similarity).
 MOD_RES 367 367 Phosphoserine (By similarity).
 MOD_RES 827 827 N6-acetyllysine (By similarity).
 MOD_RES 1019 1019 Phosphoserine.  
Keyword
 Acetylation; Activator; Complete proteome; Notch signaling pathway; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1020 AA 
Protein Sequence
MVLPTCPMAE FALPRHSAVM ERLRRRIELC RRHHSTCEAR YEAVSPERLE LERQHTFALH 60
QRCIQAKAKR AGKHRQPPAA ATAPVAAPAP ASAPAAARLD AADGPEHGRP VAHLHDTVKR 120
SLDSAASPQN GDQPNGYGDL FPGHKKTRRE APLGVSVSAN GLPPASPLGQ PDKPSGGDTL 180
QTAGKHSLGL DPINKKCLAD SGIHLNGGSN SSEPFPLSLS KELKQEPVDD LPCMIAGAGG 240
SVAQSNLMPD LNLNEQEWKE LIEELNRSVP DEDMKDLFTE DFEEKKDPEP PGSATQTPLA 300
QDINIKTEFS PAAFEQEQLG SPQVRAGSAG QTFLGASSAP VGTDSPSLGS SQTLFHTTSQ 360
PGVDNSSPNL MPASAQAQSA QRALTSVVLP SQGPGGASEL SSAHQLQQIA AKQKREQMLQ 420
NPQQAAPAPG PGQLATWQQA GPSHSPLDVP YPMEKPASPS GYKQDFTNSK LLMMPGVNKS 480
SPRPGGPYLQ PSHSNLLSHQ SPSNLNQNPV NNQGSVLDYG NTKPLSHYKA DCGQGGPGSG 540
QNKPALMAYL PQQLPHLSNE QNSLFLMKPK SGNMPFRSLV PPGQEQNPSS VPVAAPAASV 600
GTQPTVSVAS THNSSPYLSS QQQAAVMKQH QLLLDQQKQR EQQQQQLQQQ QFLQRQHLLA 660
EQEKQQFQRH LTRPPPQYQD PTQSTFPQQV GQFTGPSAAV PGMNNLGPSN SSCPRVFPQP 720
GTLMSMGPGH APVSSLPSSS GQQDRGVAQF TGSQSLPQNS LYGMASGLAQ IVAQPPPQAT 780
STHAHIPRQT NVGQNASTSA AYGQNSLGSA SLSQQHSKGT LPPGLTKPQV PRVSAAMGSQ 840
NASWQHQGMP NLSSQTSGNS SVNPFTAAPS FHIQQAHLKL AGQQFSQAMP SRPMAPLSSA 900
GAAGPMLPPV SAQQRNSAPA SAPPQAAPQQ GLPGLSPSGP ELGAFGQSPT SQMSGRPGLH 960
CAQAYPVRTM GQELPFAYSG QPGSSGLSSV AGHTDLIDSL LKNRTSEEWI NELDDLLGSQ 1020 
Gene Ontology
 GO:0002193; C:MAML1-RBP-Jkappa- ICN1 complex; IEA:Compara.
 GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0042605; F:peptide antigen binding; IEA:Compara.
 GO:0003713; F:transcription coactivator activity; IDA:MGI.
 GO:0060928; P:atrioventricular node cell development; IMP:BHF-UCL.
 GO:0045445; P:myoblast differentiation; IEP:UniProtKB.
 GO:0007219; P:Notch signaling pathway; IDA:UniProtKB.
 GO:0010831; P:positive regulation of myotube differentiation; IGI:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0006468; P:protein phosphorylation; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR019082; Neuroggenic_mastermind-like_N. 
Pfam
 PF09596; MamL-1 
SMART
  
PROSITE
  
PRINTS