CPLM-018678

Genbank Nucleotide ID

Leucine-rich repeat-containing protein 59

Protein Synonyms/Alias

Mus musculus (Mouse)

Position	Peptide	Type	References
40	KELAALPKATVLDLS	ubiquitination	[1]
73	KLDLSKNKLQQLPAD	acetylation	[2, 3, 4, 5, 6, 7]
73	KLDLSKNKLQQLPAD	succinylation	[6]
73	KLDLSKNKLQQLPAD	ubiquitination	[1]
108	PVSFAQLKNLKWLDL	acetylation	[3, 8]
108	PVSFAQLKNLKWLDL	ubiquitination	[1]
111	FAQLKNLKWLDLKDN	acetylation	[8]
116	NLKWLDLKDNPLDPV	acetylation	[8]
116	NLKWLDLKDNPLDPV	ubiquitination	[1]
126	PLDPVLAKVAGDCLD	ubiquitination	[1]
135	AGDCLDEKQCKQCAN	acetylation	[3, 6, 7]
135	AGDCLDEKQCKQCAN	ubiquitination	[1]
143	QCKQCANKVLQHMKA	acetylation	[3]
149	NKVLQHMKAVQADQE	acetylation	[3, 6]
149	NKVLQHMKAVQADQE	succinylation	[6]

[1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
[2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
Simon GM, Cheng J, Gordon JI.
Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
[3] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
[4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
PLoS One. 2012;7(12):e50545. [PMID: 23236377]
[5] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
[6] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
[7] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
[8] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]

Functional Description

Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores (By similarity).

REPEAT 10 31 LRR 1.
REPEAT 40 62 LRR 2.
REPEAT 63 84 LRR 3.
REPEAT 86 107 LRR 4.
REPEAT 109 128 LRR 5.
MOD_RES 23 23 Phosphoserine (By similarity).
MOD_RES 25 25 Phosphoserine (By similarity).

Coiled coil; Complete proteome; Endoplasmic reticulum; Leucine-rich repeat; Membrane; Microsome; Nucleus; Phosphoprotein; Reference proteome; Repeat; Signal-anchor; Transmembrane; Transmembrane helix.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0042645; C:mitochondrial nucleoid; IEA:Compara.
GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.

IPR001611; Leu-rich_rpt.