UniProt Accession

 CISD1_RAT; B0K020 

Genbank Protein ID

 CH473988; BC159419 

Genbank Nucleotide ID

 EDL97255.1; AAI59420.1 

Protein Name

 CDGSH iron-sulfur domain-containing protein 1 

Protein Synonyms/Alias

 MitoNEET 

Gene Name

 Cisd1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
37	AYKKFYAKESRTKAM	acetylation	[1]
51	MVNLQIQKDNPKVVH	acetylation	[1]
55	QIQKDNPKVVHAFDM	acetylation	[1]
68	DMEDLGDKAVYCRCW	acetylation	[1]
78	YCRCWRSKKFPFCDG	acetylation	[1]
79	CRCWRSKKFPFCDGA	acetylation	[1]
89	FCDGAHIKHNEETGD	acetylation	[1]
104	NVGPLIIKKKET***	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation (By similarity). May be involved in Fe-S cluster shuttling and/or in redox reactions (By similarity). 

Sequence Annotation

 METAL 72 72 Iron-sulfur (2Fe-2S) (By similarity).
 METAL 74 74 Iron-sulfur (2Fe-2S) (By similarity).
 METAL 83 83 Iron-sulfur (2Fe-2S) (By similarity).
 METAL 87 87 Iron-sulfur (2Fe-2S); via pros nitrogen
 MOD_RES 104 104 N6-acetyllysine (By similarity).  

Keyword

 2Fe-2S; Acetylation; Complete proteome; Iron; Iron-sulfur; Membrane; Metal-binding; Mitochondrion; Mitochondrion outer membrane; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 108 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
 GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0043457; P:regulation of cellular respiration; IEA:Compara. 

Interpro

 IPR018967; FeS-contain_CDGSH-typ.
 IPR006622; FeS-contain_CDGSH-typ_subfam.
 IPR019610; FeS-contain_mitoNEET_N. 

Pfam

 PF10660; MitoNEET_N
 PF09360; zf-CDGSH 

SMART

 SM00704; ZnF_CDGSH 

PROSITE

  

PRINTS