CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031939
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 BTB/POZ domain-containing protein 10 
Protein Synonyms/Alias
 cDNA FLJ57269, highly similar to BTB/POZ domain-containing protein 10; cDNA, FLJ79062, highly similar to BTB/POZ domain-containing protein 10 
Gene Name
 BTBD10 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
165VFVYENAKEGARNIRubiquitination[1, 2, 3]
219NFTRPNEKGEYEVAEubiquitination[1, 2, 3, 4, 5]
241RAILDYYKTGIIRCPubiquitination[2, 5, 6]
429HVDFQCVKSKSITNLubiquitination[2, 4]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 483 AA 
Protein Sequence
MPKDADLAFS ASLFERAESL YTLISKFFSC FCVSTLAYTK GSTSSRIAKG GVDHTKMSLH 60
GASGGHERSR DRRRSSDRSR DSSHERTESQ LTPCIRNVTS PTRQHHVERE KDHSSSRPSS 120
PRPQKASPNG SISSAGNSSR NSSQSSSDGS CKTAGEMVFV YENAKEGARN IRTSERVTLI 180
VDNTRFVVDP SIFTAQPNTM LGRMFGSGRE HNFTRPNEKG EYEVAEGIGS TVFRAILDYY 240
KTGIIRCPDG ISIPELREAC DYLCISFEYS TIKCRDLSAL MHELSNDGAR RQFEFYLEEM 300
ILPLMVASAQ SGERECHIVV LTDDDVVDWD EEYPPQMGEE YSQIIYSTKL YRFFKYIENR 360
DVAKSVLKER GLKKIRLGIE GYPTYKEKVK KRPGGRPEVI YNYVQRPFIR MSWEKEEGKS 420
RHVDFQCVKS KSITNLAAAA ADIPQDQLVV MHPTPQVDEL DILPIHPPSG NSDLDPDAQN 480
PML 483 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA. 
Interpro
 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold. 
Pfam
  
SMART
 SM00225; BTB 
PROSITE
  
PRINTS