CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000512
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 8-amino-7-oxononanoate synthase 1 
Protein Synonyms/Alias
 AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase 
Gene Name
 kbl 
Gene Synonyms/Alias
 BSU17000 
Created Date
 July 27, 2013 
Organism
 Bacillus subtilis (strain 168) 
NCBI Taxa ID
 224308 
Lysine Modification
Position
Peptide
Type
References
240IQVGTLSKAIGVLGGacetylation[1]
Reference
 [1] The acetylproteome of Gram-positive model bacterium Bacillus subtilis.
 Kim D, Yu BJ, Kim JA, Lee YJ, Choi SG, Kang S, Pan JG.
 Proteomics. 2013 May;13(10-11):1726-36. [PMID: 23468065] 
Functional Description
 Catalyzes the decarboxylative condensation of pimeloyl- [acyl-carrier protein] and L-alanine to produce 8-amino-7- oxononanoate (AON), [acyl-carrier protein], and carbon dioxide (By similarity). 
Sequence Annotation
 REGION 109 110 Pyridoxal phosphate binding (By
 REGION 206 209 Pyridoxal phosphate binding (By
 REGION 237 240 Pyridoxal phosphate binding (By
 BINDING 134 134 Substrate (By similarity).
 BINDING 181 181 Pyridoxal phosphate (By similarity).
 BINDING 354 354 Substrate (By similarity).
 MOD_RES 240 240 N6-(pyridoxal phosphate)lysine  
Keyword
 Acyltransferase; Biotin biosynthesis; Complete proteome; Pyridoxal phosphate; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 392 AA 
Protein Sequence
MTKEFEFLKA ELNSMKENHT WQDIKQLESM QGPSVTVNHQ KVIQLSSNNY LGFTSHPRLI 60
NAAQEAVQQY GAGTGSVRTI AGTFTMHQEL EKKLAAFKKT EAALVFQSGF TTNQGVLSSI 120
LSKEDIVISD ELNHASIIDG IRLTKADKKV YQHVNMSDLE RVLRKSMNYR MRLIVTDGVF 180
SMDGNIAPLP DIVELAEKYD AFVMVDDAHA SGVLGENGRG TVNHFGLDGR VHIQVGTLSK 240
AIGVLGGYAA GSKVLIDYLR HKGRPFLFST SHPPAVTAAC MEAIDVLLEE PEHMERLWEN 300
TAYFKAMLVK MGLTLTKSET PILPILIGDE GVAKQFSDQL LSRGVFAQSI VFPTVAKGKA 360
RIRTIITAEH TKDELDQALD VIEKTAKELQ LL 392 
Gene Ontology
 GO:0008710; F:8-amino-7-oxononanoate synthase activity; ISS:UniProtKB.
 GO:0008890; F:glycine C-acetyltransferase activity; ISS:UniProtKB.
 GO:0030170; F:pyridoxal phosphate binding; ISS:UniProtKB.
 GO:0009102; P:biotin biosynthetic process; ISS:UniProtKB. 
Interpro
 IPR001917; Aminotrans_II_pyridoxalP_BS.
 IPR004839; Aminotransferase_I/II.
 IPR004723; BioF.
 IPR010962; PyrdxlP-dep_AcTrfase_put.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2. 
Pfam
 PF00155; Aminotran_1_2 
SMART
  
PROSITE
 PS00599; AA_TRANSFER_CLASS_2 
PRINTS