UniProt Accession

 AK1BA_HUMAN; O60218; A4D1P1; O75890; Q6FHF3; Q8IWZ1 

Genbank Protein ID

 U37100; AF052577; AF524864; BT006794; CR541801; AC078847; CH236950; CH471070; BC008837; AF044961 

Genbank Nucleotide ID

 AAC17469.1; AAC36465.1; AAO13380.1; AAP35440.1; CAG46600.1; EAL24069.1; EAW83816.1; AAH08837.1; AAC15671.1 

Protein Name

 Aldo-keto reductase family 1 member B10 

Protein Synonyms/Alias

 ARL-1; Aldose reductase-like; Aldose reductase-related protein; ARP; hARP; Small intestine reductase; SI reductase 

Gene Name

 AKR1B10 

Gene Synonyms/Alias

 AKR1B11 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
27	TWKSPLGKVKEAVKV	acetylation	[1]
69	KIQEKAVKREDLFIV	acetylation	[1]
95	LVRKAFEKTLKDLKL	acetylation	[1]
125	SGDDLFPKDDKGNAI	acetylation	[1]
179	NKPGLKYKPVTNQVE	acetylation	[1]
263	RNVIVIPKSVTPARI	acetylation	[1]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. 

Sequence Annotation

 NP_BIND 20 22 NADP.
 NP_BIND 160 161 NADP.
 NP_BIND 210 217 NADP.
 NP_BIND 261 273 NADP.
 ACT_SITE 49 49 Proton donor.
 BINDING 44 44 NADP.
 BINDING 111 111 Substrate.
 BINDING 184 184 NADP.
 MOD_RES 125 125 N6-acetyllysine.
 MOD_RES 263 263 N6-acetyllysine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Lysosome; NADP; Oxidoreductase; Polymorphism; Reference proteome; Secreted. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 316 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
 GO:0004033; F:aldo-keto reductase (NADP) activity; TAS:UniProtKB.
 GO:0045550; F:geranylgeranyl reductase activity; IDA:UniProtKB.
 GO:0047718; F:indanol dehydrogenase activity; IDA:UniProtKB.
 GO:0001758; F:retinal dehydrogenase activity; IDA:UniProtKB.
 GO:0006081; P:cellular aldehyde metabolic process; TAS:ProtInc.
 GO:0044597; P:daunorubicin metabolic process; IMP:UniProtKB.
 GO:0007586; P:digestion; TAS:ProtInc.
 GO:0044598; P:doxorubicin metabolic process; IMP:UniProtKB.
 GO:0016488; P:farnesol catabolic process; IDA:UniProtKB.
 GO:0007603; P:phototransduction, visible light; TAS:Reactome.
 GO:0001523; P:retinoid metabolic process; TAS:Reactome.
 GO:0008202; P:steroid metabolic process; TAS:ProtInc. 

Interpro

 IPR001395; Aldo/ket_red.
 IPR018170; Aldo/ket_reductase_CS.
 IPR020471; Aldo/keto_reductase_subgr.
 IPR023210; NADP_OxRdtase_dom. 

Pfam

 PF00248; Aldo_ket_red 

SMART

  

PROSITE

 PS00798; ALDOKETO_REDUCTASE_1
 PS00062; ALDOKETO_REDUCTASE_2
 PS00063; ALDOKETO_REDUCTASE_3 

PRINTS

 PR00069; ALDKETRDTASE.