CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039053
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Uba2 
Protein Synonyms/Alias
  
Gene Name
 Uba2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
181STGYDPVKLFTKLFKacetylation[1]
188KLFTKLFKDDIRYLLacetylation[1]
199RYLLTMDKLWRKRKPacetylation[1]
431ETEANNPKKLSDFGIubiquitination[2]
552ENEGASTKKSRLEQVacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Ligase; Nucleotide-binding; Reference proteome; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 569 AA 
Protein Sequence
SQVAKESVLQ FHPQANIEAH HDSIMNPDYN VEFFRQFILV MNALDNRAAR NHVNRMCLAA 60
DVPLIESGTA GYLGQVTTIK KGVTECYECH PKPTQRTFPG CTIRNTPSEP IHCIVWAKYL 120
FNQLFGEEDA DQEVSPDRAD PEAAWEPTEA EARARASNED GDIKRISTKE WAKSTGYDPV 180
KLFTKLFKDD IRYLLTMDKL WRKRKPPVPL DWAEVQSQGE EANADQQSEP QLGLKDQQVL 240
DVKSYASLFS KSIETLRVRL AEKGDGAELI WDKDDPPAMD FVTSAANLRM HIFSMNMKSR 300
FDIKSMAGNI IPAIATTNAV IAGLIVLEGL KILSGKIDQC RTIFLNKQPN PRKKLLVPCA 360
LDPPNTNCYV CASKPEVTVR LNVHKVTVLT LQDKIVKEKF AMVAPDVQIE DGKGTILISS 420
EEGETEANNP KKLSDFGIRN GSRLQADDFL QDYTLLINIL HSEDLGKDVE FEVVGDTPEK 480
VGPKQAEDAA KSIANGSDDG AQPSTSTEQA QEQDDVLIVD SDEEGPSNSA DGSRDDRTRK 540
RKLEENEGAS TKKSRLEQVE DQDDVIALD 569 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
 GO:0019948; F:SUMO activating enzyme activity; IEA:Compara.
 GO:0006464; P:cellular protein modification process; IEA:InterPro. 
Interpro
 IPR009036; Molybdenum_cofac_synth_MoeB.
 IPR016040; NAD(P)-bd_dom.
 IPR000594; ThiF_NAD_FAD-bd.
 IPR023280; Ub-like_act_enz_cat_cys_dom.
 IPR000127; UBact_repeat.
 IPR019572; Ubiquitin-activating_enzyme.
 IPR018074; UBQ-activ_enz_E1_AS. 
Pfam
 PF00899; ThiF
 PF10585; UBA_e1_thiolCys
 PF02134; UBACT 
SMART
  
PROSITE
 PS00536; UBIQUITIN_ACTIVAT_1
 PS00865; UBIQUITIN_ACTIVAT_2 
PRINTS