UniProt Accession

 PGDH_HUMAN; P15428; B4DTA4; B4DU74; B4DV57; D3DP43; E7EV11; O00749; Q06F08 

Genbank Protein ID

 L76465; J05594; U63296; AK296642; AK300125; AK300524; AK300940; AK314624; DQ903072; AC096751; CH471056; CH471056; CH471056; CH471056; BC018986 

Genbank Nucleotide ID

 AAA89175.1; AAA89174.1; AAB53034.1; BAH12408.1; BAG61916.1; BAG62236.1; BAG62569.1; BAG37190.1; ABI75347.1; EAX04734.1; EAX04735.1; EAX04736.1; EAX04737.1; AAH18986.1 

Protein Name

 15-hydroxyprostaglandin dehydrogenase [NAD(+)] 

Protein Synonyms/Alias

 15-PGDH; Prostaglandin dehydrogenase 1 

Gene Name

 HPGD 

Gene Synonyms/Alias

 PGDH1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
28	FAEALLLKGAKVALV	ubiquitination	[1]
31	ALLLKGAKVALVDWN	ubiquitination	[1]
57	DEQFEPQKTLFIQCD	ubiquitination	[1]
77	QLRDTFRKVVDHFGR	ubiquitination	[1]
98	NAGVNNEKNWEKTLQ	ubiquitination	[1]
249	IMKITTSKGIHFQDY	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells. 

Sequence Annotation

 NP_BIND 12 20 NAD.
 NP_BIND 36 37 NAD.
 NP_BIND 63 65 NAD.
 NP_BIND 151 155 NAD.
 NP_BIND 186 188 NAD.
 ACT_SITE 151 151 Proton acceptor.
 BINDING 91 91 NAD; via carbonyl oxygen.
 BINDING 138 138 Substrate (Probable).
 BINDING 148 148 Substrate (Probable).  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Fatty acid metabolism; Lipid metabolism; NAD; Oxidoreductase; Polymorphism; Prostaglandin metabolism; Reference proteome; Tumor suppressor. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 266 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; NAS:UniProtKB.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0016404; F:15-hydroxyprostaglandin dehydrogenase (NAD+) activity; IDA:UniProtKB.
 GO:0070403; F:NAD+ binding; IDA:UniProtKB.
 GO:0004957; F:prostaglandin E receptor activity; IDA:UniProtKB.
 GO:0042803; F:protein homodimerization activity; TAS:UniProtKB.
 GO:0019371; P:cyclooxygenase pathway; TAS:Reactome.
 GO:0097070; P:ductus arteriosus closure; ISS:UniProtKB.
 GO:0007565; P:female pregnancy; IDA:UniProtKB.
 GO:2001300; P:lipoxin metabolic process; TAS:Reactome.
 GO:0019372; P:lipoxygenase pathway; TAS:UniProtKB.
 GO:0045786; P:negative regulation of cell cycle; IDA:UniProtKB.
 GO:0030728; P:ovulation; ISS:UniProtKB.
 GO:0007567; P:parturition; IDA:UniProtKB.
 GO:0070493; P:thrombin receptor signaling pathway; ISS:UniProtKB.
 GO:0007179; P:transforming growth factor beta receptor signaling pathway; IDA:UniProtKB. 

Interpro

 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom.
 IPR020904; Sc_DH/Rdtase_CS. 

Pfam

 PF00106; adh_short 

SMART

  

PROSITE

 PS00061; ADH_SHORT 

PRINTS

 PR00081; GDHRDH.
 PR00080; SDRFAMILY.