UniProt Accession

 PACN2_MOUSE; Q9WVE8 

Genbank Protein ID

 AF128535; BC023502 

Genbank Nucleotide ID

 AAD41780.1; AAH23502.1 

Protein Name

 Protein kinase C and casein kinase substrate in neurons protein 2 

Protein Synonyms/Alias

 Syndapin 2; Syndapin-II 

Gene Name

 Pacsin2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
53	HERARIEKAYAQQLT	acetylation	[1, 2]
72	RWRQLVEKGPQYGTV	ubiquitination	[3]
177	ISREANSKADPSLNP	ubiquitination	[3]
264	LSNVASYKTIYRELE	acetylation	[1]
264	LSNVASYKTIYRELE	ubiquitination	[3]
275	RELEQSIKAADAVED	ubiquitination	[3]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Plays a role in the formation of normal, flask-shaped caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis. Plays a role in intracellular vesicle-mediated transport. Binds to membranes via its F-BAR domain and promotes membrane tubulation. Plays a role in the internalization of cell-surface receptors. Is not required for internalization of EGFR after EGF stimulus, but contributes to the internalization of EGFR in the absence of EGF stimulus. 

Sequence Annotation

 DOMAIN 11 75 FCH.
 DOMAIN 426 486 SH3.
 REGION 1 306 F-BAR domain.  

Keyword

 3D-structure; Cell membrane; Cell projection; Coiled coil; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Cytoskeleton; Endocytosis; Endosome; Lipid-binding; Membrane; Phosphoprotein; Reference proteome; SH3 domain. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 486 AA 

Protein Sequence

Gene Ontology

 GO:0005901; C:caveola; IDA:UniProtKB.
 GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
 GO:0019898; C:extrinsic to membrane; IDA:UniProtKB.
 GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
 GO:0008092; F:cytoskeletal protein binding; IDA:MGI.
 GO:0008289; F:lipid binding; IDA:UniProtKB.
 GO:0070836; P:caveola assembly; ISS:UniProtKB.
 GO:0072584; P:caveolin-mediated endocytosis; ISS:UniProtKB.
 GO:0048858; P:cell projection morphogenesis; IMP:UniProtKB.
 GO:0097320; P:membrane tubulation; IMP:UniProtKB.
 GO:0045806; P:negative regulation of endocytosis; IDA:MGI.
 GO:0007165; P:signal transduction; TAS:MGI. 

Interpro

 IPR001060; FCH_dom.
 IPR001452; SH3_domain. 

Pfam

 PF00611; FCH
 PF00018; SH3_1 

SMART

 SM00055; FCH
 SM00326; SH3 

PROSITE

 PS50133; FCH
 PS50002; SH3 

PRINTS

 PR00452; SH3DOMAIN.