| Tag | Content |
|---|
| CPLM ID | CPLM-018714 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Gamma-butyrobetaine dioxygenase |
Protein Synonyms/Alias | Gamma-butyrobetaine hydroxylase; Gamma-BBH; Gamma-butyrobetaine,2-oxoglutarate dioxygenase |
Gene Name | Bbox1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 49 | DCYLHSAKARKLLLE | ubiquitination | [1] | | 240 | DGFNVCQKLKEKNPQ | ubiquitination | [1] | | 283 | KIIELDDKGQVVRVN | ubiquitination | [1] | | 324 | FVDLMNSKEYKYTFK | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Catalyzes the formation of L-carnitine from gamma- butyrobetaine (By similarity). |
Sequence Annotation | METAL 38 38 Zinc (By similarity).
METAL 40 40 Zinc (By similarity).
METAL 43 43 Zinc (By similarity).
METAL 82 82 Zinc (By similarity).
METAL 202 202 Iron; catalytic (By similarity).
METAL 204 204 Iron; catalytic (By similarity).
METAL 347 347 Iron; catalytic (By similarity). |
Keyword | Carnitine biosynthesis; Complete proteome; Cytoplasm; Dioxygenase; Iron; Metal-binding; Oxidoreductase; Reference proteome; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 387 AA |
Protein Sequence | MHCAILKAEA VDGAHLMQIF WHDGAESLYP AVWLRDNCQC SDCYLHSAKA RKLLLEALDV 60
NIRIDDLTFD RKKVYITWPN DHYSEFEANW LKKRCFSQQA RARLQGELFL PECQYWGSEL 120
QLPTLNFEDV LNDDDHAYKW LSSLKKVGIV RLTGAADKRG EIIKLGKRIG FLYLTFYGHT 180
WQVQDKIDAN NVAYTTGKLS FHTDYPALHH PPGVQLLHCI KQTVTGGDSE IVDGFNVCQK 240
LKEKNPQAFH ILSSTFVDFT DIGVDYCDFS VQSKHKIIEL DDKGQVVRVN FNNATRDTVF 300
DVPIERVQPF YAALKEFVDL MNSKEYKYTF KMNPGDVITF DNWRLLHGRR SYEAGTEISR 360
HLEGAYADWD VVMSRLRILR QRVTNGN 387 |
Gene Ontology | GO:0015629; C:actin cytoskeleton; IEA:Compara. GO:0005739; C:mitochondrion; IDA:MGI. GO:0008336; F:gamma-butyrobetaine dioxygenase activity; ISS:UniProtKB. GO:0005506; F:iron ion binding; IEA:InterPro. GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:UniProtKB-KW. GO:0008270; F:zinc ion binding; ISS:UniProtKB. GO:0045329; P:carnitine biosynthetic process; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |