CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016612
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Gamma-secretase subunit APH-1A 
Protein Synonyms/Alias
 APH-1a; Aph-1alpha 
Gene Name
 Aph1a 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
96AYYKLLKKADEGLASubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex (By similarity). 
Sequence Annotation
  
Keyword
 Alternative splicing; Complete proteome; Endoplasmic reticulum; Golgi apparatus; Membrane; Notch signaling pathway; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 265 AA 
Protein Sequence
MGAAVFFGCT FVAFGPAFSL FLITVAGDPL RVIILVAGAF FWLVSLLLAS VVWFILVHVT 60
DRSDARLQYG LLIFGAAVSV LLQEVFRFAY YKLLKKADEG LASLSEDGRS PISIRQMAYV 120
SGLSFGIISG VFSVINILAD ALGPGVVGIH GDSPYYFLTS AFLTAAIILL HTFWGVVFFD 180
ACERRRYWAL GLVVGSHLLT SGLTFLNPWY EASLLPIYAV TVSMGLWAFI TAGGSLRSIQ 240
RSLSCRRQED SRVMVYSALR IPPED 265 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
 GO:0005887; C:integral to plasma membrane; ISS:UniProtKB.
 GO:0004175; F:endopeptidase activity; IDA:MGI.
 GO:0042987; P:amyloid precursor protein catabolic process; IEA:Compara.
 GO:0006509; P:membrane protein ectodomain proteolysis; ISS:UniProtKB.
 GO:0031293; P:membrane protein intracellular domain proteolysis; IEA:Compara.
 GO:0001656; P:metanephros development; IMP:MGI.
 GO:0007220; P:Notch receptor processing; IMP:MGI.
 GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
 GO:0043085; P:positive regulation of catalytic activity; ISS:UniProtKB.
 GO:0016485; P:protein processing; ISS:UniProtKB. 
Interpro
 IPR009294; Aph-1. 
Pfam
 PF06105; Aph-1 
SMART
  
PROSITE
  
PRINTS