UniProt Accession

 HRH1_MOUSE; P70174; Q91V75; Q91XN0; Q91XN1; Q91XN2; Q91XN3 

Genbank Protein ID

 D50095; AF387890; AF387891; AF387892; AF387893; AF387894; AF387895; AF387896; AF388052; AF388053; AF388054; AF388055; AF388056; AF388057; AF388058; AK032763; AK038480; AK046607; AK047070 

Genbank Nucleotide ID

 BAA08791.1; AAK71654.1; AAK71655.1; AAK71656.1; AAK71657.1; AAK71658.1; AAK71659.1; AAK71660.1; AAK66774.2; AAK66775.1; AAK66776.1; AAK66777.1; AAK66778.1; AAK66779.1; AAK66780.1; BAC28011.1; BAC30013.1; BAC32805.1; BAC32950.1 

Protein Name

 Histamine H1 receptor 

Protein Synonyms/Alias

 H1R; HH1R 

Gene Name

 Hrh1 

Gene Synonyms/Alias

 Bphs 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
376	EPGLGKVKARSRSNS	acetylation	[1]
376	EPGLGKVKARSRSNS	succinylation	[1]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. Involved in circadian rhythm of locomotor activity and exploratory behavior. Also involved in responsiveness to pertussis toxin through its control of susceptibility to histamine hypersensitivity and enhancement of antigen-specific delayed-type hypersensitivity responses. 

Sequence Annotation

 MOD_RES 140 140 Phosphothreonine (By similarity).
 MOD_RES 142 142 Phosphothreonine (By similarity).
 MOD_RES 397 397 Phosphoserine (By similarity).
 MOD_RES 399 399 Phosphoserine (By similarity).
 LIPID 446 446 S-palmitoyl cysteine (Potential).
 CARBOHYD 5 5 N-linked (GlcNAc...) (Potential).
 CARBOHYD 18 18 N-linked (GlcNAc...) (Potential).
 DISULFID 100 180 By similarity.  

Keyword

 Biological rhythms; Cell membrane; Complete proteome; Disulfide bond; G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Transducer; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 488 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0015085; F:calcium ion transmembrane transporter activity; ISO:MGI.
 GO:0004969; F:histamine receptor activity; IEA:InterPro.
 GO:0070509; P:calcium ion import; ISO:MGI.
 GO:0071420; P:cellular response to histamine; ISO:MGI.
 GO:0007204; P:elevation of cytosolic calcium ion concentration; IEA:InterPro.
 GO:0048245; P:eosinophil chemotaxis; IEA:InterPro.
 GO:0071421; P:manganese ion transmembrane transport; ISO:MGI.
 GO:0007613; P:memory; IMP:MGI.
 GO:0045907; P:positive regulation of vasoconstriction; IEA:InterPro.
 GO:0030814; P:regulation of cAMP metabolic process; IEA:InterPro.
 GO:0048167; P:regulation of synaptic plasticity; IMP:MGI.
 GO:0043114; P:regulation of vascular permeability; IEA:InterPro.
 GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
 GO:0008542; P:visual learning; IMP:MGI. 

Interpro

 IPR000276; GPCR_Rhodpsn.
 IPR017452; GPCR_Rhodpsn_7TM.
 IPR000921; Histamine_H1_rcpt. 

Pfam

 PF00001; 7tm_1 

SMART

  

PROSITE

 PS00237; G_PROTEIN_RECEP_F1_1
 PS50262; G_PROTEIN_RECEP_F1_2 

PRINTS

 PR00237; GPCRRHODOPSN.
 PR00530; HISTAMINEH1R.